Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors
about
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ ReductionBACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseSmall-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).Advances in the identification of β-secretase inhibitors.The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.New directions for protease inhibitors directed drug discovery.Retrospective molecular docking study of WY-25105 ligand to β-secretase and bias of the three-dimensional structure flexibility.Chemometric design to explore pharmacophore features of BACE inhibitors for controlling Alzheimer's disease.Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer's Disease.The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease
P2860
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P2860
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Structure based design, synthe ...... lamine (HEA) BACE-1 inhibitors
@ast
Structure based design, synthe ...... lamine (HEA) BACE-1 inhibitors
@en
Structure based design, synthe ...... lamine (HEA) BACE-1 inhibitors
@nl
type
label
Structure based design, synthe ...... lamine (HEA) BACE-1 inhibitors
@ast
Structure based design, synthe ...... lamine (HEA) BACE-1 inhibitors
@en
Structure based design, synthe ...... lamine (HEA) BACE-1 inhibitors
@nl
prefLabel
Structure based design, synthe ...... lamine (HEA) BACE-1 inhibitors
@ast
Structure based design, synthe ...... lamine (HEA) BACE-1 inhibitors
@en
Structure based design, synthe ...... lamine (HEA) BACE-1 inhibitors
@nl
P2093
P1476
Structure based design, synthe ...... lamine (HEA) BACE-1 inhibitors
@en
P2093
Clive McCarthy
Heinrich Rueeger
Henrik Möbitz
Jean-Michel Rondeau
Marina Tintelnot-Blomley
Sandrine Desrayaud
Ulf Neumann
P304
P356
10.1016/J.BMCL.2011.02.038
P407
P577
2011-04-01T00:00:00Z