A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes - Wikidata - wikimedia - TriplyDB

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

http://www.wikidata.org/entity/Q27667526

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Histone acetyltransferases: challenges in targeting bi-substrate enzymes Dichotomy in the Epigenetic Mark Lysine Acetylation is Critical for the Proliferation of Prostate Cancer Cells The bromodomain: from epigenome reader to druggable target Protein lysine acetylation by p300/CBP Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis Targeting bromodomains: epigenetic readers of lysine acetylation Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules Azo-propofols: photochromic potentiators of GABA(A) receptors.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives Anthrax SET protein: a potential virulence determinant that epigenetically represses NF-κB activation in infected macrophages.Writers and readers of histone acetylation: structure, mechanism, and inhibition Inhibition of histone H3K9 acetylation by anacardic acid can correct the over-expression of Gata4 in the hearts of fetal mice exposed to alcohol during pregnancy.Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.Perspectives on the discovery of small-molecule modulators for epigenetic processes.A chromatin link to caste identity in the carpenter ant Camponotus floridanus BET bromodomain inhibitors: a patent review.BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy Fluorinated aromatic amino acids are sensitive 19F NMR probes for bromodomain-ligand interactions.3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds Molecular dynamic simulation insights into the normal state and restoration of p53 function.Scaling the druggability landscape of human bromodomains, a new class of drug targets.Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteins Chromatin as an expansive canvas for chemical biology.Bromodomains as therapeutic targets.Progress in the discovery of small-molecule inhibitors of bromodomain--histone interactions.The bromodomain interaction module.Epigenetic chemical probes.Readout of epigenetic modifications.Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.Bromodomains and their pharmacological inhibitors.Size does matter! Label-free detection of small molecule-protein interaction.

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A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

http://www.wikidata.org/entity/Q27667526

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

A Small Molecule Binding to th ...... ks Apoptosis in Cardiomyocytes

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A Small Molecule Binding to th ...... ks Apoptosis in Cardiomyocytes

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A Small Molecule Binding to th ...... ks Apoptosis in Cardiomyocytes

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J.CHEMBIOL.2010.12.021

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Chemistry and Biology

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A Small Molecule Binding to th ...... ks Apoptosis in Cardiomyocytes

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Guillermo Gerona-Navarro

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Ioannis Karakikes

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Jagat C Borah

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Jigneshkumar Patel

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Keita Morohashi

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Lei Zeng

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Michaela Muller

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Ming-Ming Zhou

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Natasha Moshkina

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Roger J Hajjar

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P2860

Structure and ligand of a histone acetyltransferase bromodomain

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

Acetylation of histones and transcription-related factors

The role of human bromodomains in chromatin biology and gene transcription

Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation

Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300

Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein

The transcriptional coactivators p300 and CBP are histone acetyltransferases

Surfing the p53 network

Suppression of p53: a new approach to overcome side effects of antitumor therapy

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10.1016/J.CHEMBIOL.2010.12.021

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51070963

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21513889

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apoptotic process

clinical chemistry

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3103858

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