Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains - Wikidata - wikimedia - TriplyDB

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

http://www.wikidata.org/entity/Q28242369

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Targeting Protein-Protein Interactions in the HIF System Open access chemical probes for epigenetic targets Protein lysine acetylation by p300/CBP Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy CBP/p300 Bromodomains Regulate Amyloid-like Protein Aggregation upon Aberrant Lysine Acetylation Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition Structural diversity of the epigenetics pocketome.Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.ETS-targeted therapy: can it substitute for MEK inhibitors?Epigenetic Strategies to Boost Cancer Immunotherapies.Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules.BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation.CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112.Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.Selective targeting of Bromodomains of the Bromodomain-PHD Fingers family impairs osteoclast differentiation.Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.Progress in the Development of non-BET Bromodomain Chemical Probes.Toward personalized management in bladder cancer: the promise of novel molecular taxonomy.Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma Epigenetic regulation of cardiac fibrosis.Selective targeting of epigenetic reader domains.Epigenetics: A primer for clinicians.Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Structural features and inhibitors of bromodomains.Bromodomain inhibitors and cancer therapy: From structures to applications.Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.Chemical modulators for epigenome reader domains as emerging epigenetic therapies for cancer and inflammation.9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.

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P2860

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

http://www.wikidata.org/entity/Q28242369

description

2014 nî lūn-bûn

@nan

2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

@ast

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

@en

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

@nl

type

label

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

@ast

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

@en

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

@nl

prefLabel

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

@ast

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

@en

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

@nl

P1433

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P1433

Journal of the American Chemical Society

P1476

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

@en

P2093

Anthony Tumber

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Catherine M Rogers

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Christopher Wells

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Clarence Yapp

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Cynthia Tallant

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Dean C Singleton

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Duncan A Hay

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Mark E Bunnage

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Martin Philpott

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Octovia P Monteiro

http://www.w3.org/2001/XMLSchema#string

P2860

Selective inhibition of BET bromodomains

Histone recognition and large-scale structural analysis of the human bromodomain family

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination

The role of human bromodomains in chromatin biology and gene transcription

Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation

Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300

Suppression of inflammation by a synthetic histone mimic

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9308-19

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scholarly article

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2056352

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10.1021/JA412434F

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P433

26

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136

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Christopher J. Schofield

Panagis Filippakopoulos

Stuart J. Conway

Susanne Müller

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2014-07-02T00:00:00Z

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263295501

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24946055

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