Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors - Wikidata - wikimedia - TriplyDB

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

http://www.wikidata.org/entity/Q27667904

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G-protein-coupled receptor kinase 2 and endothelial dysfunction: molecular insights and pathophysiological mechanisms Targeting G protein coupled receptor-related pathways as emerging molecular therapies Finding a better path to drug selectivity Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility Structural and Functional Analysis of G Protein-Coupled Receptor Kinase Inhibition by Paroxetine and a Rationally Designed Analog Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals.Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking.Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.Molecular basis for small molecule inhibition of G protein-coupled receptor kinases G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor G protein-coupled receptor kinases: more than just kinases and not only for GPCRs Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth.Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1).Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.Inhibition of G-protein-coupled receptor kinase 2 (GRK2) triggers the growth-promoting mitogen-activated protein kinase (MAPK) pathway.Structural insights into G protein-coupled receptor kinase function.Beyond traditional pharmacology: new tools and approaches.Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.The interplay between G protein-coupled receptor kinase 2 (GRK2) and histone deacetylase 6 (HDAC6) at the crossroads of epithelial cell motility.Endothelial Dysfunction in Obesity.Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog.The Role of G Protein-coupled Receptor Kinases in Cancer.The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.

P2860

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P2860

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

http://www.wikidata.org/entity/Q27667904

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

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2011年論文

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2011年论文

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name

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

@ast

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

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Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

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type

label

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

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Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

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Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

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prefLabel

Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

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Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

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Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

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Molecular Pharmacology

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Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors

@en

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Christian Schoenau

http://www.w3.org/2001/XMLSchema#string

David M Thal

http://www.w3.org/2001/XMLSchema#string

Jochen Huber

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John J G Tesmer

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Raymond Y Yeow

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P2860

Molecular basis for activation of G protein-coupled receptor kinases

The protein kinase complement of the human genome

Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5

MolProbity: all-atom structure validation for macromolecular crystallography

Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor Balanol

Use of TLS parameters to model anisotropic displacements in macromolecular refinement

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294-303

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10.1124/MOL.111.071522

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2

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80

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51150775

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21596927

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G protein-coupled receptor

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3141885

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