An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme - Wikidata - wikimedia - TriplyDB

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

http://www.wikidata.org/entity/Q27670465

about

Specific small molecule inhibitors of Skp2-mediated p27 degradation Drugging the undruggables: exploring the ubiquitin system for drug development Novel strategies to target the ubiquitin proteasome system in multiple myeloma K11-linked ubiquitin chains as novel regulators of cell division Targeting the ubiquitin pathway for cancer treatment Building and remodelling Cullin-RING E3 ubiquitin ligases Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex Selective Recruitment of an E2 Ubiquitin Complex by an E3 Ubiquitin Ligase E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G CLMSVault: A Software Suite for Protein Cross-Linking Mass-Spectrometry Data Analysis and Visualization.Cell division cycle 34 is highly expressed in hepatitis C virus-positive hepatocellular carcinoma with favorable phenotypes.Structural and functional insights to ubiquitin-like protein conjugation.A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Targeting cullin-RING ligases for cancer treatment: rationales, advances and therapeutic implications.Equilibrium fluctuations of a single folded protein reveal a multitude of potential cryptic allosteric sites.Loop 7 of E2 enzymes: an ancestral conserved functional motif involved in the E2-mediated steps of the ubiquitination cascade.BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein.Target identification of small molecules based on chemical biology approaches.An electrophoretic mobility shift assay identifies a mechanistically unique inhibitor of protein sumoylation.Development of inhibitors in the ubiquitination cascade.Discovery of multiple hidden allosteric sites by combining Markov state models and experiments Downregulation of ubiquitin inhibits the proliferation and radioresistance of non-small cell lung cancer cells in vitro and in vivo.Sculpting the proteome with small molecules Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control.Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting.Bioinformatics and variability in drug response: a protein structural perspective.Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application E2 superfamily of ubiquitin-conjugating enzymes: constitutively active or activated through phosphorylation in the catalytic cleft.Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases.Inhibiting the protein ubiquitination cascade by ubiquitin-mimicking short peptides.Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase.The ubiquitin-conjugating enzyme CDC34 is essential for cytokinesis in contrast to putative subunits of a SCF complex in Trypanosoma brucei.The Colossus of ubiquitylation: decrypting a cellular code.The role of allostery in the ubiquitin-proteasome system

P2860

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P2860

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

http://www.wikidata.org/entity/Q27670465

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

@ast

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

@en

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

@nl

type

label

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

@ast

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

@en

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

@nl

prefLabel

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

@ast

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

@en

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

@nl

P1433

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P577

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P5875

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P3181

P356

J.CELL.2011.05.039

P1433

P1476

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme

@en

P2093

Abdallah Al-Hakim

http://www.w3.org/2001/XMLSchema#string

Abiodun Ogunjimi

http://www.w3.org/2001/XMLSchema#string

Antonia Lopez-Girona

http://www.w3.org/2001/XMLSchema#string

Benoit Pelletier

http://www.w3.org/2001/XMLSchema#string

Dante Neculai

http://www.w3.org/2001/XMLSchema#string

David R Webb

http://www.w3.org/2001/XMLSchema#string

Frank Mercurio

http://www.w3.org/2001/XMLSchema#string

Jeff Wrana

http://www.w3.org/2001/XMLSchema#string

Joanna Koszela

http://www.w3.org/2001/XMLSchema#string

Mike Tyers

http://www.w3.org/2001/XMLSchema#string

P304

1075-87

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P31

scholarly article

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5106388

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P356

10.1016/J.CELL.2011.05.039

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P407

P433

7

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P478

145

http://www.w3.org/2001/XMLSchema#string

P50

Sirano Dhe-Paganon

Daniel Durocher

Xaralabos Varelas

Derek F Ceccarelli

Gregory A Wasney

P577

2011-06-24T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51228926

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P698

21683433

http://www.w3.org/2001/XMLSchema#string

P921

allosteric inhibitor