Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
about
Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategiesJAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indicationsStructural and physico-chemical effects of disease and non-disease nsSNPs on proteinsJAK2 activation by growth hormone and other cytokinesStructure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinasesStructure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibitionJAK/STAT pathway dysregulation in tumors: a Drosophila perspectiveTyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.Pseudokinases: update on their functions and evaluation as new drug targets.Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistanceStructure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-bindingMechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analysesThe molecular regulation of Janus kinase (JAK) activationIntegrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemiaA robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.Mechanism of activation of protein kinase JAK2 by the growth hormone receptor.CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.Ab initio modeling and experimental assessment of Janus Kinase 2 (JAK2) kinase-pseudokinase complex structure.Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele.ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activationMolecular insights into regulation of JAK2 in myeloproliferative neoplasmsPAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia.The molecular basis of IL-10 function: from receptor structure to the onset of signaling.Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).Uncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.Redox regulation of Janus kinase: The elephant in the room.Molecular pathways: molecular basis for sensitivity and resistance to JAK kinase inhibitors.Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia.Dawn of the dead: protein pseudokinases signal new adventures in cell biology.Techniques to examine nucleotide binding by pseudokinases.A pickup in pseudokinase activity.New insights into the structure and function of the pseudokinase domain in JAK2.Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers.Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family.Pseudokinase drug intervention: a potentially poisoned chalice.Therapeutic targeting of the Jak/STAT pathway.Kinases and pseudokinases: lessons from RAF.A new mechanism for growth hormone receptor activation of JAK2, and implications for related cytokine receptors.Going for broke: targeting the human cancer pseudokinome.
P2860
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P2860
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
@ast
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
@en
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
@nl
type
label
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
@ast
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
@en
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
@nl
prefLabel
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
@ast
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
@en
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
@en
P2093
David E Shaw
Rajintha M Bandaranayake
Yibing Shan
P2860
P2888
P3181
P356
10.1038/NSMB.2348
P577
2012-08-01T00:00:00Z
P5875
P6179
1040261037