Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains
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Structural diversity of eukaryotic membrane cytochrome p450sConformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine MoleculesInvestigation by site-directed mutagenesis of the role of cytochrome P450 2B4 non-active-site residues in protein-ligand interactions based on crystal structures of the ligand-bound enzymeX-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocketSteroid-based facial amphiphiles for stabilization and crystallization of membrane proteins.A Structural Snapshot of CYP2B4 in Complex with Paroxetine Provides Insights into Ligand Binding and Clusters of Conformational StatesStructural and Thermodynamic Basis of (+)-α-Pinene Binding to Human Cytochrome P450 2B6Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison.Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevanceStructure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic MetabolismSubstrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling.Conformational diversity and ligand tunnels of mammalian cytochrome P450s.Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes.Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame.Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry.Structure-Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz.Roles of Residues F206 and V367 in Human CYP2B6: Effects of Mutations on Androgen Hydroxylation, Mechanism-Based Inactivation, and Reversible Inhibition.Use of phenoxyaniline analogs to generate biochemical insights into polybrominated diphenyl ether interaction with CYP2B enzymes.Analysis of Species-Selectivity of Human, Mouse and Rat Cytochrome P450 1A and 2B Subfamily Enzymes using Molecular Modeling, Docking and Dynamics Simulations.Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog.
P2860
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P2860
Structures of Cytochrome P450 2B6 Bound to 4-Benzylpyridine and 4-(4-Nitrobenzyl)pyridine: Insight into Inhibitor Binding and Rearrangement of Active Site Side Chains
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Structures of Cytochrome P450 ...... ent of Active Site Side Chains
@ast
Structures of Cytochrome P450 ...... ent of Active Site Side Chains
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Structures of Cytochrome P450 ...... ent of Active Site Side Chains
@nl
type
label
Structures of Cytochrome P450 ...... ent of Active Site Side Chains
@ast
Structures of Cytochrome P450 ...... ent of Active Site Side Chains
@en
Structures of Cytochrome P450 ...... ent of Active Site Side Chains
@nl
prefLabel
Structures of Cytochrome P450 ...... ent of Active Site Side Chains
@ast
Structures of Cytochrome P450 ...... ent of Active Site Side Chains
@en
Structures of Cytochrome P450 ...... ent of Active Site Side Chains
@nl
P2093
P2860
P356
P1476
Structures of cytochrome P450 ...... ent of active site side chains
@en
P2093
C David Stout
James R Halpert
Qinghai Zhang
P2860
P304
P356
10.1124/MOL.111.074427
P577
2011-08-29T00:00:00Z