Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine - Wikidata - wikimedia - TriplyDB

Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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Exploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computation Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels Open-channel structures of the human glycine receptor α1 full-length transmembrane domain.Insights into Distinct Modulation of 7 and 7 2 Nicotinic Acetylcholine Receptors by the Volatile Anesthetic Isoflurane Comparing crystal structures of Ca(2+) -ATPase in the presence of different lipids Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses Critical role of water in the binding of volatile anesthetics to proteins.A membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel.Cellular registration without behavioral recall of olfactory sensory input under general anesthesia.Atomistic insights into human Cys-loop receptors by solution NMR.Atomistic models of general anesthetics for use in in silico biological studies Recent insights into the mode of action of memantine and ketamine Conformational changes in acetylcholine binding protein investigated by temperature accelerated molecular dynamics.Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors.Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.Conformational Changes Underlying Desensitization of the Pentameric Ligand-Gated Ion Channel ELIC.Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.Enzyme Tunnels and Gates As Relevant Targets in Drug Design.NMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChR Muscle-Type Nicotinic Receptor Blockade by Diethylamine, the Hydrophilic Moiety of Lidocaine.Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels.The Ascaris suum nicotinic receptor, ACR-16, as a drug target: Four novel negative allosteric modulators from virtual screening.Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptors Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites.A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation.Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes.Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors.Direct interaction of the resistance to inhibitors of cholinesterase type 3 protein with the serotonin receptor type 3A intracellular domain.The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?The cellular membrane as a mediator for small molecule interaction with membrane proteins.Photoaffinity labeling the propofol binding site in GLIC.Study, by use of coarse-grained models, of the functionally crucial residues and allosteric pathway of anesthetic regulation of the Gloeobacter violaceus ligand-gated ion channel.Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC.Ketamine Inhibition of the Pentameric Ligand-Gated Ion Channel GLIC.

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

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Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine

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Christopher B Divito

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Dan Willenbring

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David Mowrey

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Jianjun Pan

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Pei Tang

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Qiang Chen

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Yan Xu

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Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-α-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors

Crystal structure of the extracellular domain of nAChR alpha1 bound to alpha-bungarotoxin at 1.94 A resolution

Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin

Atomic interactions of neonicotinoid agonists with AChBP: Molecular recognition of the distinctive electronegative pharmacophore

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

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