Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor. - Wikidata - wikimedia - TriplyDB

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.

http://www.wikidata.org/entity/Q35616147

about

Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.A Novel Lid-Covering Peptide Inhibitor of Nicotinic Acetylcholine Receptors Derived from αD-Conotoxin GeXXA.Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands.Current Treatment, Emerging Translational Therapies, and New Therapeutic Targets for Autoimmune Myasthenia Gravis.Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.The Ascaris suum nicotinic receptor, ACR-16, as a drug target: Four novel negative allosteric modulators from virtual screening.Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine-Binding Protein as a Structural Surrogate.Biophysics: for HTS hit validation, chemical lead optimization, and beyond.Developments in SPR Fragment Screening.Understanding structure-function relationships of the human neuronal acetylcholine receptor: insights from the first crystal structures of neuronal subunits.Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery.Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels.The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors.Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors.Nicotinic acetylcholine receptors at the single-channel level.Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine binding protein.Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists Based on the Spirocyclic Quinuclidine-Δ2 -Isoxazoline Scaffold: Synthesis and Electrophysiological Evaluation.Theoretical study of the binding profile of an allosteric modulator NS-1738 with a chimera structure of the α7 nicotinic acetylcholine receptor.Competitive docking model for prediction of the human nicotinic acetylcholine receptor α7 binding of tobacco constituents.

P2860

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P2860

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.

http://www.wikidata.org/entity/Q35616147

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

@zh-tw

2015年论文

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2015年论文

@zh

2015年论文

@zh-cn

name

Molecular blueprint of alloste ...... otinic acetylcholine receptor.

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Molecular blueprint of alloste ...... otinic acetylcholine receptor.

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type

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Molecular blueprint of alloste ...... otinic acetylcholine receptor.

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Molecular blueprint of alloste ...... otinic acetylcholine receptor.

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prefLabel

Molecular blueprint of alloste ...... otinic acetylcholine receptor.

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Molecular blueprint of alloste ...... otinic acetylcholine receptor.

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PNAS.1418289112

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Molecular blueprint of alloste ...... cotinic acetylcholine receptor

@en

P2093

Ana Farinha

http://www.w3.org/2001/XMLSchema#string

Chris Ulens

http://www.w3.org/2001/XMLSchema#string

Daniel Bertrand

http://www.w3.org/2001/XMLSchema#string

Ken Veys

http://www.w3.org/2001/XMLSchema#string

Radovan Spurny

http://www.w3.org/2001/XMLSchema#string

Sarah Debaveye

http://www.w3.org/2001/XMLSchema#string

Sonia Bertrand

http://www.w3.org/2001/XMLSchema#string

Thomas Gossas

http://www.w3.org/2001/XMLSchema#string

U Helena Danielson

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P2860

A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors

MolProbity: all-atom structure validation for macromolecular crystallography

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex

Size matters in activation/inhibition of ligand-gated ion channels

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

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E2543-52

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scholarly article

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10.1073/PNAS.1418289112

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25918415

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4434711

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