Subunit Stabilization and Polyethylene Glycolation of Cocaine Esterase Improves In Vivo Residence Time
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Rational Design, Preparation, and Characterization of a Therapeutic Enzyme Mutant with Improved Stability and Function for Cocaine DetoxificationA thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primatesThe ability of bacterial cocaine esterase to hydrolyze cocaine metabolites and their simultaneous quantification using high-performance liquid chromatography-tandem mass spectrometryThe fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination.Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addictionLong-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.Nano-antidotes for drug overdose and poisoning.Alpha/beta-hydrolases: A unique structural motif coordinates catalytic acid residue in 40 protein fold families.Protein engineering of the antitumor enzyme PpADI for improved thermal resistance.
P2860
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P2860
Subunit Stabilization and Polyethylene Glycolation of Cocaine Esterase Improves In Vivo Residence Time
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Subunit Stabilization and Poly ...... mproves In Vivo Residence Time
@ast
Subunit Stabilization and Poly ...... mproves In Vivo Residence Time
@en
Subunit Stabilization and Poly ...... mproves In Vivo Residence Time
@nl
type
label
Subunit Stabilization and Poly ...... mproves In Vivo Residence Time
@ast
Subunit Stabilization and Poly ...... mproves In Vivo Residence Time
@en
Subunit Stabilization and Poly ...... mproves In Vivo Residence Time
@nl
prefLabel
Subunit Stabilization and Poly ...... mproves In Vivo Residence Time
@ast
Subunit Stabilization and Poly ...... mproves In Vivo Residence Time
@en
Subunit Stabilization and Poly ...... mproves In Vivo Residence Time
@nl
P2093
P2860
P356
P1476
Subunit Stabilization and Poly ...... mproves In Vivo Residence Time
@en
P2093
Diwahar Narasimhan
Elin Edwald
Gregory T Collins
James H Woods
Jimmy Chan
John J G Tesmer
Joseph Nichols
Mark R Nance
Mei-Chuan Ko
Roger K Sunahara
P2860
P304
P356
10.1124/MOL.111.074997
P577
2011-12-01T00:00:00Z