The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
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Pharmacological chaperoning: a primer on mechanism and pharmacologyPharmacological chaperones for human -N-acetylgalactosaminidaseStructural snapshots illustrate the catalytic cycle of β-galactocerebrosidase, the defective enzyme in Krabbe disease.New therapeutic approaches for Krabbe disease: The potential of pharmacological chaperonesIdentification of an Allosteric Binding Site on Human Lysosomal Alpha-Galactosidase Opens the Way to New Pharmacological Chaperones for Fabry DiseaseFrom structural biology to designing therapy for inborn errors of metabolismUsing pharmacological chaperones to restore proteostasisThe development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases.Candidate molecules for chemical chaperone therapy of GM1-gangliosidosis.Carboxyl-terminal truncations alter the activity of the human α-galactosidase APharmacological chaperone therapy for lysosomal storage diseases.Ligand and Target Discovery by Fragment-Based Screening in Human Cells.A thermodynamic assay to test pharmacological chaperones for Fabry disease.Anderson-Fabry cardiomyopathy: prevalence, pathophysiology, diagnosis and treatment.Pharmacological Chaperone Therapy: Preclinical Development, Clinical Translation, and Prospects for the Treatment of Lysosomal Storage Disorders.Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases.Functional and Clinical Consequences of Novel α-Galactosidase A Mutations in Fabry Disease.Structural basis of pharmacological chaperoning for human β-galactosidase.Taming molecular flexibility to tackle rare diseases.Looking for protein stabilizing drugs with thermal shift assay.Ligand-promoted protein folding by biased kinetic partitioning.[Pharmacological chaperons: a novel therapeutic approach for genetic diseases].Pharmacological Chaperones: Beyond Conformational Disorders.Substrate and Substrate-Mimetic Chaperone Binding Sites in Human α-Galactosidase A Revealed by Affinity-Mass Spectrometry.
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The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
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2011 nî lūn-bûn
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2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
@ast
The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
@en
The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
@nl
type
label
The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
@ast
The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
@en
The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
@nl
prefLabel
The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
@ast
The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
@en
The Molecular Basis of Pharmacological Chaperoning in Human α-Galactosidase
@nl
P2093
P2860
P921
P3181
P1476
The molecular basis of pharmacological chaperoning in human α-galactosidase
@en
P2093
Abigail I Guce
Nathaniel E Clark
Scott C Garman
P2860
P304
P3181
P356
10.1016/J.CHEMBIOL.2011.10.012
P577
2011-12-01T00:00:00Z