X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
about
Effect of Iboga alkaloids on µ-opioid receptor-coupled G protein activationCrystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transportMechanisms of dopamine transporter regulation in normal and disease statesX-ray structure of dopamine transporter elucidates antidepressant mechanismR-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuseA current view of serotonin transportersMonoamine transporters: insights from molecular dynamics simulationsDesigning modulators of monoamine transporters using virtual screening techniquesThe SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunctionVisualizing functional motions of membrane transporters with molecular dynamics simulationsBehavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporterNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesHow LeuT shapes our understanding of the mechanisms of sodium-coupled neurotransmitter transportersSpontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminusA conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state.Neurotransmitter and psychostimulant recognition by the dopamine transporter.Complete mapping of substrate translocation highlights the role of LeuT N-terminal segment in regulating transport cycleExploring the conformational transitions of biomolecular systems using a simple two-state anisotropic network modelUnveiling the Mechanism of Arginine Transport through AdiC with Molecular Dynamics Simulations: The Guiding Role of Aromatic ResiduesArginine oscillation explains Na+ independence in the substrate/product antiporter CaiTStructural basis for action by diverse antidepressants on biogenic amine transportersStructural basis of the alternating-access mechanism in a bile acid transporterStructural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetPConformational changes required for H+/Cl− exchange mediated by a CLC transporterCoupled ion binding and structural transitions along the transport cycle of glutamate transportersMolecular mechanism of ligand recognition by membrane transport protein, Mhp1Structure and multistate function of the transmembrane electron transporter CcdAProtein stability: a crystallographer's perspectiveNanobodies and recombinant binders in cell biologyLigand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulationsThermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound ConformationMapping Cholesterol Interaction Sites on Serotonin Transporter through Coarse-Grained Molecular DynamicsBasic residues R260 and K357 affect the conformational dynamics of the major facilitator superfamily multidrug transporter LmrPExploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics StudyMembrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes.13C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1.A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporterConformational Changes in Two Inter-Helical Loops of Mhp1 Membrane Transporter.Repeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanisms
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P2860
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
@ast
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
@en
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
@nl
type
label
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
@ast
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
@en
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
@nl
prefLabel
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
@ast
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
@en
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
@nl
P2860
P3181
P356
P1433
P1476
X-ray structures of LeuT in substrate-free outward-open and apo inward-open states
@en
P2093
Harini Krishnamurthy
P2860
P2888
P304
P3181
P356
10.1038/NATURE10737
P407
P50
P577
2012-01-09T00:00:00Z
P5875
P6179
1021179004