The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
about
Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartmentEndocrine neoplasms in familial syndromes of hyperparathyroidismIntrinsic protein disorder in histone lysine methylation.Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motifMEN1, MEN4, and Carney Complex: Pathology and Molecular GeneticsMultiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4)A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology.MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas.Menin enhances c-Myc-mediated transcription to promote cancer progressionMenin/PRMT5/hedgehog signaling: a potential target for the treatment of multiple endocrine neoplasia type 1 tumors.FBP1 Is an Interacting Partner of Menin.Regulation of histone H3K4 methylation in brain development and disease.Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins.Menin immunoreactivity in secretory granules of human pancreatic islet cellsThe same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours.Modulation by miR-29b of intestinal epithelium homoeostasis through the repression of menin translation.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Challenges and opportunities in targeting the menin-MLL interaction.StaRProtein, a web server for prediction of the stability of repeat proteins.JunD enhances miR-29b levels transcriptionally and posttranscriptionally to inhibit proliferation of intestinal epithelial cells.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth.Multiple Endocrine Neoplasia: Genetics and Clinical Management.PTCH 1 staining of pancreatic neuroendocrine tumor (PNET) samples from patients with and without multiple endocrine neoplasia (MEN-1) syndrome reveals a potential therapeutic target.MLL1 is essential for the senescence-associated secretory phenotypeNovel variants in MLL confer to bladder cancer recurrence identified by whole-exome sequencing.A new double substitution mutation in the MEN1 gene: a limited penetrance and a specific phenotype.Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.Community Structure Reveals Biologically Functional Modules in MEF2C Transcriptional Regulatory NetworkDistinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcriptionMenin is required for optimal processing of the microRNA let-7a.Epigenetics and blood disorders.Menin as a hub controlling mixed lineage leukemia.The many facets of MLL1 regulation.In focus: MLL-rearranged leukemia.
P2860
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P2860
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The same pocket in menin binds ...... osite effects on transcription
@ast
The same pocket in menin binds ...... osite effects on transcription
@en
The same pocket in menin binds ...... osite effects on transcription
@nl
type
label
The same pocket in menin binds ...... osite effects on transcription
@ast
The same pocket in menin binds ...... osite effects on transcription
@en
The same pocket in menin binds ...... osite effects on transcription
@nl
prefLabel
The same pocket in menin binds ...... osite effects on transcription
@ast
The same pocket in menin binds ...... osite effects on transcription
@en
The same pocket in menin binds ...... osite effects on transcription
@nl
P2093
P2860
P3181
P356
P1433
P1476
The same pocket in menin binds ...... osite effects on transcription
@en
P2093
Buddha Gurung
Jing Huang
Juanita L Merchant
Natalia A Veniaminova
Smita Matkar
Xianxin Hua
P2860
P2888
P3181
P356
10.1038/NATURE10806
P407
P50
P577
2012-02-12T00:00:00Z
P5875
P6179
1048547161