Structural basis of kynurenine 3-monooxygenase inhibition
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Mitochondrial targets for pharmacological intervention in human diseaseThe flavoproteome of the yeast Saccharomyces cerevisiaeTryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolitesTargeted Deletion of Kynurenine 3-Monooxygenase in Mice: A NEW TOOL FOR STUDYING KYNURENINE PATHWAY METABOLISM IN PERIPHERY AND BRAINNatural low-molecular mass organic compounds with oxidase activity as organocatalystsKynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder.A magnetic bead-based ligand binding assay to facilitate human kynurenine 3-monooxygenase drug discovery.Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder.Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata.Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder.Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid.The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease.Bacterial expression of human kynurenine 3-monooxygenase: solubility, activity, purification.Preclinical Studies of Cannabinoid Reward, Treatments for Cannabis Use Disorder, and Addiction-Related Effects of Cannabinoid Exposure.Major developments in the design of inhibitors along the kynurenine pathway.Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Role of Kynurenine Metabolism Pathway Activation in Major Depressive Disorders.Lead discovery for human kynurenine 3-monooxygenase by high-throughput RapidFire mass spectrometry.Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases.Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenaseThe Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice.The Kynurenine 3-Monooxygenase Encoding Gene, BcKMO, Is Involved in the Growth, Development, and Pathogenicity of Botrytis cinerea.Kynurenine 3-Monooxygenase Gene Associated With Nicotine Initiation and Addiction: Analysis of Novel Regulatory Features at 5′ and 3′-Regions.The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activationMolecular profiles of tumor contrast enhancement: A radiogenomic analysis in anaplastic gliomas
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P2860
Structural basis of kynurenine 3-monooxygenase inhibition
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2013 nî lūn-bûn
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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
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2013年論文
@zh-hant
2013年論文
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2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structural basis of kynurenine 3-monooxygenase inhibition
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Structural basis of kynurenine 3-monooxygenase inhibition
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Structural basis of kynurenine 3-monooxygenase inhibition
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Structural basis of kynurenine 3-monooxygenase inhibition
@ast
Structural basis of kynurenine 3-monooxygenase inhibition
@en
Structural basis of kynurenine 3-monooxygenase inhibition
@nl
prefLabel
Structural basis of kynurenine 3-monooxygenase inhibition
@ast
Structural basis of kynurenine 3-monooxygenase inhibition
@en
Structural basis of kynurenine 3-monooxygenase inhibition
@nl
P2093
P2860
P356
P1433
P1476
Structural basis of kynurenine 3-monooxygenase inhibition
@en
P2093
Colin Levy
Derren J Heyes
Flaviano Giorgini
Marta Amaral
Nigel S Scrutton
Pierre Lafite
Tiago F Outeiro
P2860
P2888
P356
10.1038/NATURE12039
P407
P50
P577
2013-04-18T00:00:00Z
P5875
P6179
1035977536