Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling
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Computational Approaches to Toll-Like Receptor 4 ModulationDeletion of the vaccinia virus gene A46R, encoding for an inhibitor of TLR signalling, is an effective approach to enhance the immunogenicity in mice of the HIV/AIDS vaccine candidate NYVAC-CMolecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coliStructures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signalingMechanism of Bacterial Interference with TLR4 Signaling by Brucella Toll/Interleukin-1 Receptor Domain-containing Protein TcpBCrystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from the Brucella Protein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular MimicryCharacterization and Structure of the Vaccinia Virus NF-κB Antagonist A46Structure of the Toll/interleukin 1 receptor (TIR) domain of the immunosuppressive Brucella effector BtpA/Btp1/TcpBMembrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif.A non-uniform sampling approach enables studies of dilute and unstable proteins.The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling PathwayPoxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactionsThe TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.Suppression of TLR signaling by targeting TIR domain-containing proteinsA Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.Toll-like receptors in atherosclerosisCloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB.Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain.New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis.Mal, more than a bridge to MyD88.Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains.Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways.Differential adapter recruitment by TLR2 co-receptors.Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity.An in silico approach towards the identification of novel inhibitors of the TLR-4 signaling pathway.TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis.Insight into Phosphatidylinositol-Dependent Membrane Localization of the Innate Immune Adaptor Protein Toll/Interleukin 1 Receptor Domain-Containing Adaptor Protein.Structure of a prokaryotic SEFIR domain reveals two novel SEFIR-SEFIR interaction modes.Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88.Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling
P2860
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P2860
Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling
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2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structural Insights into TIR D ...... Adaptor Mal in TLR4 Signaling
@ast
Structural Insights into TIR D ...... Adaptor Mal in TLR4 Signaling
@en
Structural Insights into TIR D ...... Adaptor Mal in TLR4 Signaling
@nl
type
label
Structural Insights into TIR D ...... Adaptor Mal in TLR4 Signaling
@ast
Structural Insights into TIR D ...... Adaptor Mal in TLR4 Signaling
@en
Structural Insights into TIR D ...... Adaptor Mal in TLR4 Signaling
@nl
prefLabel
Structural Insights into TIR D ...... Adaptor Mal in TLR4 Signaling
@ast
Structural Insights into TIR D ...... Adaptor Mal in TLR4 Signaling
@en
Structural Insights into TIR D ...... Adaptor Mal in TLR4 Signaling
@nl
P2093
P2860
P1433
P1476
Structural Insights into TIR D ...... Adaptor Mal in TLR4 Signaling
@en
P2093
Weihong Zhou
Yuequan Shen
Zhijie Lin
P2860
P304
P356
10.1371/JOURNAL.PONE.0034202
P407
P577
2012-01-01T00:00:00Z