Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions
about
Deletion of the vaccinia virus gene A46R, encoding for an inhibitor of TLR signalling, is an effective approach to enhance the immunogenicity in mice of the HIV/AIDS vaccine candidate NYVAC-CCharacterization and Structure of the Vaccinia Virus NF-κB Antagonist A46Structure of vaccinia virus A46, an inhibitor of TLR4 signaling pathway, shows the conformation of VIPER motif.Inhibition of TLR4 signaling by TRAM-derived decoy peptides in vitro and in vivoTRAM is required for TLR2 endosomal signaling to type I IFN inductionToll-like receptor 4 inhibition within the paraventricular nucleus attenuates blood pressure and inflammatory response in a genetic model of hypertensionVaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain ProteinsBid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia.Multiple Bcl-2 family immunomodulators from vaccinia virus regulate MAPK/AP-1 activationPoxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitmeDeletion of the vaccinia virus N2L gene encoding an inhibitor of IRF3 improves the immunogenicity of modified vaccinia virus Ankara expressing HIV-1 antigens.The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent MechanismModulation of proinflammatory NF-κB signaling by ectromelia virus in RAW 264.7 murine macrophages.Borna disease virus possesses an NF-ĸB inhibitory sequence in the nucleoprotein geneSolution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNFα in human phagocytes.Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory.Wogonin inhibits LPS-induced inflammatory responses in rat dorsal root ganglion neurons via inhibiting TLR4-MyD88-TAK1-mediated NF-κB and MAPK signaling pathway.
P2860
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P2860
Poxviral protein A46 antagonizes Toll-like receptor 4 signaling by targeting BB loop motifs in Toll-IL-1 receptor adaptor proteins to disrupt receptor:adaptor interactions
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Poxviral protein A46 antagoniz ...... receptor:adaptor interactions
@ast
Poxviral protein A46 antagoniz ...... receptor:adaptor interactions
@en
type
label
Poxviral protein A46 antagoniz ...... receptor:adaptor interactions
@ast
Poxviral protein A46 antagoniz ...... receptor:adaptor interactions
@en
prefLabel
Poxviral protein A46 antagoniz ...... receptor:adaptor interactions
@ast
Poxviral protein A46 antagoniz ...... receptor:adaptor interactions
@en
P2860
P356
P1476
Poxviral protein A46 antagoniz ...... receptor:adaptor interactions
@en
P2093
Andrew G Bowie
Julianne Stack
P2860
P304
22672-22682
P356
10.1074/JBC.M112.349225
P407
P577
2012-05-16T00:00:00Z