Structural basis for R-spondin recognition by LGR4/5/6 receptors - Wikidata - wikimedia - TriplyDB

Structural basis for R-spondin recognition by LGR4/5/6 receptors

Structural basis for R-spondin recognition by LGR4/5/6 receptors

http://www.wikidata.org/entity/Q27678579

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Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondin Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer In a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR Family LGR4 and Its Role in Intestinal Protection and Energy Metabolism Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling N-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding Ability Crystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs).Intrinsic disorder in spondins and some of their interacting partners.Updating the Wnt pathways.The stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to β-arrestin-2 recruitment.Engineering high-potency R-spondin adult stem cell growth factors.R-Spondins Are Expressed by the Intestinal Stroma and are Differentially Regulated during Citrobacter rodentium- and DSS-Induced Colitis in Mice.R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5.Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy.Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli.LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male rats Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis.The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength Ovarian LGR5 is critical for successful pregnancy.Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification.Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca2+ pathways in human osteoarthritis osteoblasts.Morphogenesis of liver epithelial cells.Generation and characterization of monoclonal antibodies against human LGR6.WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.Mechanism of Sex Determination in Humans: Insights from Disorders of Sex Development.RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer.In Vitro Propagation and Branching Morphogenesis from Single Ureteric Bud Cells.Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.R-spondins can potentiate WNT signaling without LGRs.Probing Wnt Receptor Turnover: A Critical Regulatory Point of Wnt Pathway.LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer A growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5 intestinal stem cell maintenance

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

http://www.wikidata.org/entity/Q27678579

description

2013 nî lūn-bûn

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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2013 թվականի հունիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Structural basis for R-spondin recognition by LGR4/5/6 receptors

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

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type

label

Structural basis for R-spondin recognition by LGR4/5/6 receptors

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

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prefLabel

Structural basis for R-spondin recognition by LGR4/5/6 receptors

@ast

Structural basis for R-spondin recognition by LGR4/5/6 receptors

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

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Genes & Development

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Structural basis for R-spondin recognition by LGR4/5/6 receptors

@en

P2093

Binlu Huang

http://www.w3.org/2001/XMLSchema#string

Dongli Wang

http://www.w3.org/2001/XMLSchema#string

Senyan Zhang

http://www.w3.org/2001/XMLSchema#string

Wei Wu

http://www.w3.org/2001/XMLSchema#string

Xiaojuan Yu

http://www.w3.org/2001/XMLSchema#string

Xinquan Wang

http://www.w3.org/2001/XMLSchema#string

P2860

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor

Structure of human follicle-stimulating hormone in complex with its receptor

LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling

The R-spondin protein family

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1339-44

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scholarly article

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575733

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10.1101/GAD.219360.113

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12

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27

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2013-06-15T00:00:00Z

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237147214

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23756652

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3701189

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