Structural basis for R-spondin recognition by LGR4/5/6 receptors
about
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondinControl of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in CancerIn a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR FamilyLGR4 and Its Role in Intestinal Protection and Energy MetabolismStructural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondinStructures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for SignalingN-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding AbilityCrystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs).Intrinsic disorder in spondins and some of their interacting partners.Updating the Wnt pathways.The stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to β-arrestin-2 recruitment.Engineering high-potency R-spondin adult stem cell growth factors.R-Spondins Are Expressed by the Intestinal Stroma and are Differentially Regulated during Citrobacter rodentium- and DSS-Induced Colitis in Mice.R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5.Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy.Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cellsReconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli.LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food intake in the hypothalamus of male ratsRegulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis.The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strengthOvarian LGR5 is critical for successful pregnancy.Caenorhabditis elegans: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification.Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca2+ pathways in human osteoarthritis osteoblasts.Morphogenesis of liver epithelial cells.Generation and characterization of monoclonal antibodies against human LGR6.WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.Mechanism of Sex Determination in Humans: Insights from Disorders of Sex Development.RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer.In Vitro Propagation and Branching Morphogenesis from Single Ureteric Bud Cells.Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.R-spondins can potentiate WNT signaling without LGRs.Probing Wnt Receptor Turnover: A Critical Regulatory Point of Wnt Pathway.LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancerA growth factor-free culture system underscores the coordination between Wnt and BMP signaling in Lgr5 intestinal stem cell maintenance
P2860
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P2860
Structural basis for R-spondin recognition by LGR4/5/6 receptors
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structural basis for R-spondin recognition by LGR4/5/6 receptors
@ast
Structural basis for R-spondin recognition by LGR4/5/6 receptors
@en
Structural basis for R-spondin recognition by LGR4/5/6 receptors
@nl
type
label
Structural basis for R-spondin recognition by LGR4/5/6 receptors
@ast
Structural basis for R-spondin recognition by LGR4/5/6 receptors
@en
Structural basis for R-spondin recognition by LGR4/5/6 receptors
@nl
prefLabel
Structural basis for R-spondin recognition by LGR4/5/6 receptors
@ast
Structural basis for R-spondin recognition by LGR4/5/6 receptors
@en
Structural basis for R-spondin recognition by LGR4/5/6 receptors
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structural basis for R-spondin recognition by LGR4/5/6 receptors
@en
P2093
Binlu Huang
Dongli Wang
Senyan Zhang
Xiaojuan Yu
Xinquan Wang
P2860
P304
P3181
P356
10.1101/GAD.219360.113
P577
2013-06-15T00:00:00Z