A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis - Wikidata - wikimedia - TriplyDB

A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

http://www.wikidata.org/entity/Q27678844

about

Transcriptional network control of normal and leukaemic haematopoiesis The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis Co-repressor CBFA2T2 regulates pluripotency and germline development Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2.RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors MicroRNAs in hematopoietic development Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells.The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.Restoration of CCAAT enhancer binding protein α P42 induces myeloid differentiation and overcomes all-trans retinoic acid resistance in human acute promyelocytic leukemia NB4-R1 cells.JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.The RUNX family: developmental regulators in cancer.The RUNX1-PU.1 axis in the control of hematopoiesis.A minicircuitry of microRNA-9-1 and RUNX1-RUNX1T1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation.Runx1 Structure and Function in Blood Cell Development.AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis.Role of RUNX1 in hematological malignancies.An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics.Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia.Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization.Acetylation and deacetylation in cancer stem-like cells.A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells.AML1/ETO trans-activates c-KIT expression through the long range interaction between promoter and intronic enhancer.Emerging Roles of MTG16 in Cell-Fate Control of Hematopoietic Stem Cells and Cancer.Protein Domain Mimics as Modulators of Protein-Protein Interactions.RUNX1 and CBFβ Mutations and Activities of Their Wild-Type Alleles in AML.RUNX1-ETO Leukemia.Methylation-associated silencing of BASP1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.Genome-wide characterization of lncRNAs in acute myeloid leukemia.Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21).The Co-operation of RUNX1 with LDB1, CDK9 and BRD4 Drives Transcription Factor Complex Relocation During Haematopoietic Specification.Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex

P2860

Q27005940-84A56090-92C6-42C7-99C1-862E264D42AE Q28088295-A41AF017-28D3-4D89-8CE7-3CB20ED8C05B Q28505594-10C4FB38-BFCC-42C2-B3E9-3DF882638A75 Q30252939-3B894A50-9B93-489F-91EA-0176EFB17B8A Q30981859-39BBE948-E0CB-4976-B538-6DA9F80E0036 Q33759034-2728D248-16BE-46E3-A0B2-89EF6B8C8C5A Q34658892-109E0952-6E04-4F73-B354-273607CD064B Q35134358-A830D534-EE47-4471-81CD-65D6DCB20D62 Q35685082-800FBDF7-6235-4922-A2F6-FE763D2CF22F Q35687910-C0E8D261-5A57-4EEC-9264-2E7B2EB9184A Q35806108-E3BCF455-E63F-4105-84CF-794E2A730972 Q35904946-243E2502-D25B-492D-B977-22D2B6ED2E87 Q36140549-B0B8762F-E4B4-4DDB-B237-1C761F4F6DA3 Q36199628-C61AB91B-DB4F-4B9A-9423-7A9FA139FF54 Q36481117-808A9A50-B0EC-466E-AC8D-C6EFE8274173 Q36897128-7CCDDD9C-BD6A-4684-8817-1901FFA3FCA9 Q37679748-512027F2-CD2F-4611-BB4A-4B3973BCA6F6 Q38319972-95568946-2BD1-49D0-AD27-130A7314E7EF Q38370113-929B00FD-5570-4FAF-B7A5-BF36C5E8BEC9 Q38738895-0B87B34B-A8A2-435E-970B-25E109DF4F67 Q38775132-15D141E0-BEA7-473F-98BC-EB93A11349A8 Q38904253-F27D4503-914F-4F3A-B570-EC336D8C60E8 Q39058012-44756141-8C8F-48E2-9726-FB7057B97A87 Q39127024-48265942-AF4F-4107-811A-0BF18ADF40B4 Q40572944-2E21AB7A-5E10-4F69-B429-DB5677D58650 Q42602670-830FACAA-7CE7-49A7-93EE-9B481DBAF458 Q44885193-8313BB98-AE57-43EB-8E93-5B54DF747DFD Q46856578-41A3B341-E64E-4E45-A8F7-929978BF3996 Q47106297-F1D02824-3794-411E-9E1C-F6643C804F73 Q47284616-6C7801B3-4CAE-4E5C-A020-903ABB10A746 Q47298164-996D09A2-4405-43E1-922E-C00661B6F9D6 Q48189669-844C3B6A-5B23-4BFE-86B7-4E642445A943 Q48351573-A20EC874-C3FA-4597-B234-BD6192E58D4C Q51097615-8EF9B0A3-98D2-42BB-ADDC-EC9E073A43EE Q51097627-2D0BE259-19C0-45B1-9EAD-82C696573429 Q52718151-D08AC633-AC84-43FD-9852-CF273FF39E78 Q53190281-FC6D92D3-82FD-4420-AA6F-3DD793F86B3D Q55263355-6E456C53-E418-40C9-8B84-09AB4A5B870C Q55714869-985DE69B-4577-4083-B642-830133850649 Q58726533-4859EF03-1A2B-4EEE-AE99-AB3063463B93

P2860

A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

http://www.wikidata.org/entity/Q27678844

description

2013 nî lūn-bûn

@nan

2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

A stable transcription factor ...... 1–ETO controls leukaemogenesis

@ast

A stable transcription factor ...... 1–ETO controls leukaemogenesis

@en

A stable transcription factor ...... 1–ETO controls leukaemogenesis

@nl

type

label

A stable transcription factor ...... 1–ETO controls leukaemogenesis

@ast

A stable transcription factor ...... 1–ETO controls leukaemogenesis

@en

A stable transcription factor ...... 1–ETO controls leukaemogenesis

@nl

prefLabel

A stable transcription factor ...... 1–ETO controls leukaemogenesis

@ast

A stable transcription factor ...... 1–ETO controls leukaemogenesis

@en

A stable transcription factor ...... 1–ETO controls leukaemogenesis

@nl

P1433

Q27678844-7BC6D5C9-ECE3-4B1A-94F7-0EAA00A8CEFD

P1476

Q27678844-15D0D6D0-9279-4EC8-9B3C-8B02F7BA55BD

P2093

Q27678844-11180851-2FF8-44ED-BF2F-2099F61B3907

Q27678844-4BEAE574-C2DD-4504-98F5-3181043617FC

Q27678844-4E8E2928-96AB-42C0-B857-CFC700B79E44

Q27678844-61A05AE2-C4B8-4901-BA09-CC3691FCC538

Q27678844-67F08003-7A33-45A3-B9C0-E85AF831C778

Q27678844-8523A613-E429-4F34-8E3F-A69ABAEFA692

Q27678844-ADE2A9DD-1B97-4776-BBE9-D8F933753916

Q27678844-B035237A-892D-4A0D-A35F-FB808148080B

Q27678844-B6E4F0CC-8CAC-4CD9-B382-3B09B07B1B71

Q27678844-BA3A1319-225A-4686-A2E7-B967FBD59239

P2860

Q27678844-030A8154-2043-4BA4-B13F-CFD49820190B

Q27678844-0C658E78-F442-4559-99C9-60D891A6F150

Q27678844-19C131E1-AD61-4690-91D9-3403EF802592

Q27678844-1D5AA816-2899-4B27-944B-C9E12C72A20F

Q27678844-1DD28D29-D409-49C1-B5B7-7979565DECF7

Q27678844-21B89D04-0299-4759-B50C-9A4871E990DC

Q27678844-2A8747B5-3983-43D4-A527-89932AE8D379

Q27678844-2EE9401E-B466-4F43-8DB1-5D8736EA37E3

Q27678844-331C7C2E-65C6-4A44-A8D0-8B8F4F33E88A

Q27678844-520E4EC5-0230-4045-BA00-DA631C7C570A

P2888

Q27678844-D2133A80-1966-4964-9081-600FA70E8980

P304

Q27678844-F07DE2EB-FD6A-40A5-8CC6-3FAE2C2E076D

P31

Q27678844-42692069-9530-4FE4-9297-04A1110ABF7F

P3181

Q27678844-9C19A8EA-5E3A-4A83-B5D1-8AA01196F219

P356

Q27678844-94E20DC1-DBAF-42C8-B611-6AE1099BB839

P407

Q27678844-900A0417-A7E0-418A-8CD8-9D4133EF9CFB

P433

Q27678844-CBE90847-30FD-4632-8D38-6A6D4568066E

P478

Q27678844-C8C8D3B8-374D-497B-9EA5-7D6BD32608F5

P50

Q27678844-E63C0462-4723-4BD8-ABCE-02AD249F6A31

Q27678844-FC2AF33F-A883-4F12-A624-9DDFCEEB6CC6

P577

Q27678844-9B6379CD-D3CF-48E3-B503-C756C455CA92

P5875

Q27678844-9B466137-8CAC-46CD-BF7E-2D966EF88199

P6179

Q27678844-2EF8EFBA-3256-47E2-8145-EE5BA5971FE7

P698

Q27678844-00D0122D-77B9-4C26-917D-918AE6900346

P932

Q27678844-D1ED7946-FA2E-4157-BB2C-5BE7CC63F38D

P3181

P356

P1433

P1476

A stable transcription factor ...... 1–ETO controls leukaemogenesis

@en

P2093

Ari Melnick

http://www.w3.org/2001/XMLSchema#string

Lan Wang

http://www.w3.org/2001/XMLSchema#string

Nils Kost

http://www.w3.org/2001/XMLSchema#string

Robert G Roeder

http://www.w3.org/2001/XMLSchema#string

Stephen D Nimer

http://www.w3.org/2001/XMLSchema#string

T David Soong

http://www.w3.org/2001/XMLSchema#string

Tomoyoshi Nakadai

http://www.w3.org/2001/XMLSchema#string

Wei-Yi Chen

http://www.w3.org/2001/XMLSchema#string

Wolfgang Fischle

http://www.w3.org/2001/XMLSchema#string

Xiao-Jian Sun

http://www.w3.org/2001/XMLSchema#string

P2860

Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

Mapping and quantifying mammalian transcriptomes by RNA-Seq

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation.

P2888

P304

93-7

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4787208

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/NATURE12287

http://www.w3.org/2001/XMLSchema#string

P407

P433

7460

http://www.w3.org/2001/XMLSchema#string

P478

500

http://www.w3.org/2001/XMLSchema#string

P50

Dinshaw J. Patel

Olivier Elemento

P577

2013-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

243968288

http://www.w3.org/2001/XMLSchema#string

P6179

1013287002

http://www.w3.org/2001/XMLSchema#string

P698

23812588

http://www.w3.org/2001/XMLSchema#string

P932

3732535

http://www.w3.org/2001/XMLSchema#string