The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity - Wikidata - wikimedia - TriplyDB

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

http://www.wikidata.org/entity/Q24317706

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The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis Co-repressor CBFA2T2 regulates pluripotency and germline development C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.Megakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb.CBFbeta is critical for AML1-ETO and TEL-AML1 activity.Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation.Transcriptional control of megakaryocyte development.BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2.A distinct epigenetic signature at targets of a leukemia protein.t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.Mutations of Chromatin Structure Regulating Genes in Human Malignancies.Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification INPP4B: the new kid on the PI3K block.Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts.Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization.Mtg16/Eto2 contributes to murine T-cell development.RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the making The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.Myeloid translocation gene 16 is required for maintenance of haematopoietic stem cell quiescence.PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Roles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions.RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes.Core binding factor at the crossroads: determining the fate of the HSC.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.A Macro View of MicroRNAs: The Discovery of MicroRNAs and Their Role in Hematopoiesis and Hematologic Disease.

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P2860

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

http://www.wikidata.org/entity/Q24317706

description

2006 nî lūn-bûn

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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2006 թվականի ապրիլին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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The tetramer structure of the ...... itical for AML1/ETO's activity

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The tetramer structure of the ...... itical for AML1/ETO's activity

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J.CCR.2006.03.012

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Daisuke Sugiyama

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James Cole

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Jeff Lary

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Justin J Gaudet

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Nancy A Speck

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Stephen M Lukasik

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Yizhou Liu

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249-260

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10.1016/J.CCR.2006.03.012

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4

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9

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7164571

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16616331

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