Structural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets

Structural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets

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http://www.wikidata.org/entity/Q27678941
The LMO2 oncogene regulates DNA replication in hematopoietic cellsDistinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis.The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.Mechanisms and proteins involved in long-distance interactions.LMO2 at 25 years: a paradigm of chromosomal translocation proteins.Enforced expression of E47 has differential effects on Lmo2-induced T-cell leukemias.Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming.Genome-Wide Organization of GATA1 and TAL1 Determined at High Resolution.Spurious transcription factor binding: non-functional or genetically redundant?
P2860

Structural Basis for LMO2-Driven Recruitment of the SCL:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets

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http://www.wikidata.org/entity/Q27678941
description
2013 nî lūn-bûn
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2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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name
Structural Basis for LMO2-Driv ...... ecific Transcriptional Targets
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Structural Basis for LMO2-Driv ...... ecific Transcriptional Targets
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Structural Basis for LMO2-Driv ...... ecific Transcriptional Targets
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type
label
Structural Basis for LMO2-Driv ...... ecific Transcriptional Targets
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Structural Basis for LMO2-Driv ...... ecific Transcriptional Targets
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Structural Basis for LMO2-Driv ...... ecific Transcriptional Targets
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Structural Basis for LMO2-Driv ...... ecific Transcriptional Targets
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Structural Basis for LMO2-Driv ...... ecific Transcriptional Targets
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Structural Basis for LMO2-Driv ...... ecific Transcriptional Targets
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Structural Basis for LMO2-Driv ...... ecific Transcriptional Targets
@en
P2093
P2860
P304
P31
P356
10.1016/J.CELREP.2013.06.008
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P478
P50
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P698
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