Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase

Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase

Item
http://www.wikidata.org/entity/Q27679217
FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical SignaturesThe 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognitionDesign, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffoldThe Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study.Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy.Molecular subclasses of hepatocellular carcinoma predict sensitivity to fibroblast growth factor receptor inhibitionApproaches targeting the FGF-FGFR system: a review of the recent patent literature and associated advanced therapeutic agents.Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease.Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase.Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.Design, synthesis and biological evaluation of 4-bromo-N-(3,5-dimethoxyphenyl)benzamide derivatives as novel FGFR1 inhibitors for treatment of non-small cell lung cancer.
P2860

Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase

Item
http://www.wikidata.org/entity/Q27679217
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Protein-ligand crystal structu ...... rs of the FGFR tyrosine kinase
@ast
Protein-ligand crystal structu ...... rs of the FGFR tyrosine kinase
@en
Protein-ligand crystal structu ...... rs of the FGFR tyrosine kinase
@nl
type
label
Protein-ligand crystal structu ...... rs of the FGFR tyrosine kinase
@ast
Protein-ligand crystal structu ...... rs of the FGFR tyrosine kinase
@en
Protein-ligand crystal structu ...... rs of the FGFR tyrosine kinase
@nl
prefLabel
Protein-ligand crystal structu ...... rs of the FGFR tyrosine kinase
@ast
Protein-ligand crystal structu ...... rs of the FGFR tyrosine kinase
@en
Protein-ligand crystal structu ...... rs of the FGFR tyrosine kinase
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Protein-ligand crystal structu ...... rs of the FGFR tyrosine kinase
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921