High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity
about
Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical SensingCrystallographic analysis of an RNA polymerase σ-subunit fragment complexed with −10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein–ssDNA complexesStructural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamerBinding of an RNA aptamer and a partial peptide of a prion protein: crucial importance of water entropy in molecular recognitionDissecting the contribution of thrombin exosite I in the recognition of thrombin binding aptamerDuplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamerA regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplexPhotoresponsive Formation of an Intermolecular Minimal G-Quadruplex MotifComparison of the 'chemical' and 'structural' approaches to the optimization of the thrombin-binding aptamerMapping the affinity landscape of Thrombin-binding aptamers on 2΄F-ANA/DNA chimeric G-Quadruplex microarraysG-quadruplex structure of an anti-proliferative DNA sequence.Applications of synchrotron-based spectroscopic techniques in studying nucleic acids and nucleic acid-functionalized nanomaterialsSite specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.Unfolding mechanism of thrombin-binding aptamer revealed by molecular dynamics simulation and Markov State Model.Crystal structure of a DNA aptamer bound to PvLDH elucidates novel single-stranded DNA structural elements for folding and recognition.Ammonium ion binding to DNA G-quadruplexes: do electrospray mass spectra faithfully reflect the solution-phase species?An overview of biological macromolecule crystallization.Structural Characterization of a Thrombin-Aptamer Complex by High Resolution Native Top-Down Mass Spectrometry.Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.An internal charge transfer-DNA platform for fluorescence sensing of divalent metal ions.Optimization of fluorescent 8-heteroaryl-guanine probes for monitoring protein-mediated duplex → G-quadruplex exchange.Different duplex/quadruplex junctions determine the properties of anti-thrombin aptamers with mixed folding.A family of DNA aptamers with varied duplex region length that forms complexes with thrombin and prothrombin.Detection of two isomeric binding configurations in a protein-aptamer complex with a biological nanopore.Anomeric DNA quadruplexes.G-triplex structure and formation propensity.Stability and bioactivity of thrombin binding aptamers modified with D-/L-isothymidine in the loop regions.5-Hydroxymethyl-2'-deoxyuridine residues in the thrombin binding aptamer: investigating anticoagulant activity by making a tiny chemical modification.Unfolding and conformational variations of thrombin-binding DNA aptamers: synthesis, circular dichroism and molecular dynamics simulations.Nucleic acid aptamers in cancer research, diagnosis and therapy.Design, synthesis and properties of artificial nucleic acids from (R)-4-amino-butane-1,3-diol.Harnessing G-tetrad scaffolds within G-quadruplex forming aptamers for fluorescence detection strategies.Specific loop modifications of the thrombin-binding aptamer trigger the formation of parallel structures.Functional isoDNA aptamers: modified thrombin binding aptamers with a 2'-5'-linked sugar-phosphate backbone (isoTBA).Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule.Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers.A Universal Base in a Specific Role: Tuning up a Thrombin Aptamer with 5-Nitroindole.Uncovering Large-Scale Conformational Change in Molecular Dynamics without Prior Knowledge.On Characterizing the Interactions between Proteins and Guanine Quadruplex Structures of Nucleic Acids.Visualizing correlated motion with HDBSCAN clustering.
P2860
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P2860
High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
High-resolution structures of ...... he aptamer inhibitory activity
@ast
High-resolution structures of ...... he aptamer inhibitory activity
@en
High-resolution structures of ...... he aptamer inhibitory activity
@nl
type
label
High-resolution structures of ...... he aptamer inhibitory activity
@ast
High-resolution structures of ...... he aptamer inhibitory activity
@en
High-resolution structures of ...... he aptamer inhibitory activity
@nl
prefLabel
High-resolution structures of ...... he aptamer inhibitory activity
@ast
High-resolution structures of ...... he aptamer inhibitory activity
@en
High-resolution structures of ...... he aptamer inhibitory activity
@nl
P2860
P50
P3181
P356
P1476
High-resolution structures of ...... he aptamer inhibitory activity
@en
P2860
P304
P3181
P356
10.1093/NAR/GKS512
P407
P577
2012-09-01T00:00:00Z