The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
about
Self-assembled DNA nanostructures for distance-dependent multivalent ligand-protein bindingCrystal structure of an RNA aptamer bound to thrombinThe effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotidesNot so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystalNucleic acid aptamers: an emerging frontier in cancer therapyA DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assemblyBinding of -thrombin to surface-anchored platelet glycoprotein Ib sulfotyrosines through a two-site mechanism involving exosite IStructural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junctionThrombin-aptamer recognition: a revealed ambiguityHigh-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activityStructural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamerStructure of Nucleophosmin DNA-binding Domain and Analysis of Its Complex with a G-quadruplex Sequence from the c-MYC PromoterThe yeast telomere-binding protein RAP1 binds to and promotes the formation of DNA quadruplexes in telomeric DNA.Aptamer-Drug ConjugatesProbing the limits of aptamer affinity with a microfluidic SELEX platformComparison of the 'chemical' and 'structural' approaches to the optimization of the thrombin-binding aptamerModulation of the Coagulation Cascade Using AptamersEncapsulating a single G-quadruplex aptamer in a protein nanocavityFunctional nucleic acid sensorsNMR structure refinement and dynamics of the K+-[d(G3T4G3)]2 quadruplex via particle mesh Ewald molecular dynamics simulations.Nucleic acid-passivated semiconductor nanocrystals: biomolecular templating of form and function.Acyclic identification of aptamers for human alpha-thrombin using over-represented libraries and deep sequencing.Thrombin inhibition by serpins disrupts exosite IIPossible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer.Conformational changes in quadruplex oligonucleotide structures probed by Raman spectroscopyApplications of synchrotron-based spectroscopic techniques in studying nucleic acids and nucleic acid-functionalized nanomaterialsSelective light-triggered release of DNA from gold nanorods switches blood clotting on and off.Biophysical and biological properties of quadruplex oligodeoxyribonucleotidesExplaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexesUsing azobenzene incorporated DNA aptamers to probe molecular binding interactions.d(G3T4G3) forms an asymmetric diagonally looped dimeric quadruplex with guanosine 5'-syn-syn-anti and 5'-syn-anti-anti N-glycosidic conformationsSite specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution.The effect on quadruplex stability of North-nucleoside derivatives in the loops of the thrombin-binding aptamer.The role of thrombin exosites I and II in the activation of human coagulation factor V.Single-molecule investigation of G-quadruplex using a nanopore sensor.Strong anion exchange for studying protein-DNA interactions by H/D exchange mass spectrometry.Unfolding mechanism of thrombin-binding aptamer revealed by molecular dynamics simulation and Markov State Model.Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions.
P2860
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P2860
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
description
1993 nî lūn-bûn
@nan
1993 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
@ast
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
@en
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
@nl
type
label
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
@ast
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
@en
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
@nl
prefLabel
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
@ast
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
@en
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
@nl
P2093
P3181
P356
P1476
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer
@en
P2093
A Tulinsky
J D Ferrara
J E Sadler
K P Padmanabhan
K Padmanabhan
P304
P3181
P356
10.2210/PDB1HUT/PDB
P407
P577
1993-08-25T00:00:00Z