Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY - Wikidata - wikimedia - TriplyDB

Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

http://www.wikidata.org/entity/Q27679983

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Expanding the Binding Envelope of CYP51 Inhibitors TargetingTrypanosoma cruziwith 4-Aminopyridyl-Based Sulfonamide Derivatives Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition 4-Aminopyridyl-Based CYP51 Inhibitors as Anti- Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition Drug strategies targeting CYP51 in neglected tropical diseases Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.Interactions of antiparasitic sterols with sterol 14α-demethylase (CYP51) of human pathogens Development and application of a sensitive, phenotypic, high-throughput image-based assay to identify compound activity against Trypanosoma cruzi amastigotes Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs.VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi.Design or screening of drugs for the treatment of Chagas disease: what shows the most promise?Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development.Chagas disease drug discovery: toward a new era.Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.Efficient electrochemical N-alkylation of N-boc-protected 4-aminopyridines: towards new biologically active compounds.In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani: A comparison with Trypanosoma cruzi Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design.Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles.3-pyridyl inhibitors with novel activity against Trypanosoma cruzi reveal in vitro profiles can aid prediction of putative cytochrome P450 inhibition.

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Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITY

http://www.wikidata.org/entity/Q27679983

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2013 nî lūn-bûn

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2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2013年の論文

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JBC.M113.497990

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Journal of Biological Chemistry

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Complexes of Trypanosoma cruzi ...... BASIS FOR PATHOGEN SELECTIVITY

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Catherine J Perez

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Eric Chatelain

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Galina I Lepesheva

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Jason H Chaplin

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Martine Keenan

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Michael R Waterman

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Paul W Alexander

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Susan A Charman

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Tatiana Y Hargrove

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P2860

Structural basis of human CYP51 inhibition by antifungal azoles

Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease

VNI cures acute and chronic experimental Chagas disease

CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

Structural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterol

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

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10.1074/JBC.M113.497990

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44

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288

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Zdzislaw Wawrzak

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2013-11-01T00:00:00Z

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256763807

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Trypanosoma cruzi

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3814756

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