Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors
about
Discovery of Mer kinase inhibitors by virtual screening using Structural Protein-Ligand Interaction Fingerprints.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor.Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancerStructure-Based Virtual Screening of Commercially Available Compound Libraries.Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitorsSmall Molecule Inhibition of MERTK Is Efficacious in Non-Small Cell Lung Cancer Models Independent of Driver Oncogene Status.Alignment independent 3D-QSAR, quantum calculations and molecular docking of Mer specific tyrosine kinase inhibitors as anticancer drugs.Structural elucidation of the DFG-Asp in and DFG-Asp out states of TAM kinases and insight into the selectivity of their inhibitors.Pseudo-cyclic structures of mono- and di-azaderivatives of malondialdehydes. Synthesis and conformational disentanglement by computational analyses.Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines.
P2860
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P2860
Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors
description
2013 nî lūn-bûn
@nan
2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Pseudo-Cyclization through Int ...... s as New Mer Kinase Inhibitors
@ast
Pseudo-Cyclization through Int ...... s as New Mer Kinase Inhibitors
@en
Pseudo-Cyclization through Int ...... s as New Mer Kinase Inhibitors
@nl
type
label
Pseudo-Cyclization through Int ...... s as New Mer Kinase Inhibitors
@ast
Pseudo-Cyclization through Int ...... s as New Mer Kinase Inhibitors
@en
Pseudo-Cyclization through Int ...... s as New Mer Kinase Inhibitors
@nl
prefLabel
Pseudo-Cyclization through Int ...... s as New Mer Kinase Inhibitors
@ast
Pseudo-Cyclization through Int ...... s as New Mer Kinase Inhibitors
@en
Pseudo-Cyclization through Int ...... s as New Mer Kinase Inhibitors
@nl
P2093
P2860
P356
P1476
Pseudo-Cyclization through Int ...... s as New Mer Kinase Inhibitors
@en
P2093
Christopher Cummings
Deborah DeRyckere
Debra Hunter
Dehui Zhang
Dmitri Kireev
Douglas K Graham
Gregory Kirkpatrick
H Shelton Earp
Jacqueline Norris-Drouin
Michael A Stashko
P2860
P304
P356
10.1021/JM401387J
P407
P577
2013-12-12T00:00:00Z