Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants
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2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibitionThe ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.Mutations in the Human AAA+ Chaperone p97 and Related DiseasesNucleotide-dependent conformational changes of the AAA+ ATPase p97 revisitedAltered cofactor regulation with disease-associated p97/VCP mutationsControl of p97 function by cofactor bindingThe N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domainsSingle site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing.Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy.The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100.Inhibitors of the AAA+ chaperone p97Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell.Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain.The Ankrd13 Family of Ubiquitin-interacting Motif-bearing Proteins Regulates Valosin-containing Protein/p97 Protein-mediated Lysosomal Trafficking of Caveolin 1.Structure and function of the AAA+ ATPase p97/Cdc48p.A Dynamic molecular basis for malfunction in disease mutants of p97/VCP.p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions.Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants.Structural mechanisms of chaperone mediated protein disaggregation.Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.Arsenic Compromises Both p97 and Proteasome Functions.Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes.A conserved inter-domain communication mechanism regulates the ATPase activity of the AAA-protein Drg1Structural basis for nucleotide-modulated p97 association with the ER membrane.Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding.Exploiting conformational plasticity in the AAA+ protein VCP/p97 to modify function.Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes.
P2860
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P2860
Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants
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2013 nî lūn-bûn
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2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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Altered Intersubunit Communica ...... ects of Pathogenic p97 Mutants
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Altered Intersubunit Communica ...... ects of Pathogenic p97 Mutants
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Altered Intersubunit Communica ...... ects of Pathogenic p97 Mutants
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Altered Intersubunit Communica ...... ects of Pathogenic p97 Mutants
@ast
Altered Intersubunit Communica ...... ects of Pathogenic p97 Mutants
@en
Altered Intersubunit Communica ...... ects of Pathogenic p97 Mutants
@nl
prefLabel
Altered Intersubunit Communica ...... ects of Pathogenic p97 Mutants
@ast
Altered Intersubunit Communica ...... ects of Pathogenic p97 Mutants
@en
Altered Intersubunit Communica ...... ects of Pathogenic p97 Mutants
@nl
P2860
P3181
P356
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Altered Intersubunit Communica ...... ects of Pathogenic p97 Mutants
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P2093
P2860
P304
P3181
P356
10.1074/JBC.M113.488924
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P577
2013-12-20T00:00:00Z