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Structural Insights into Competitive Antagonism in NMDA Receptors

Structural Insights into Competitive Antagonism in NMDA Receptors

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A structural biology perspective on NMDA receptor pharmacology and function Crystal structure of a heterotetrameric NMDA receptor ion channel Activation of NMDA receptors and the mechanism of inhibition by ifenprodil.Mechanism of NMDA Receptor Inhibition and Activation.Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.Glycine-dependent activation of NMDA receptors.Emerging structural insights into the function of ionotropic glutamate receptors.Conformational Selection and Submillisecond Dynamics of the Ligand-binding Domain of the N-Methyl-d-aspartate Receptor Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains.Prediction of N-Methyl-D-Aspartate Receptor GluN1-Ligand Binding Affinity by a Novel SVM-Pose/SVM-Score Combinatorial Ensemble Docking Scheme Computationally Discovered Potentiating Role of Glycans on NMDA Receptors.Gating Motions and Stationary Gating Properties of Ionotropic Glutamate Receptors: Computation Meets Electrophysiology.Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.Deeper Insights into the Allosteric Modulation of Ionotropic Glutamate Receptors.Heteromerization of ligand binding domains of N-methyl-D-aspartate receptor requires both coagonists, L-glutamate and glycine.Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.Semiclosed Conformations of the Ligand-Binding Domains of NMDA Receptors during Stationary Gating.Single-molecule patch-clamp FRET microscopy studies of NMDA receptor ion channel dynamics in living cells: revealing the multiple conformational states associated with a channel at its electrical off state.Novel Functional Properties of Drosophila CNS Glutamate Receptors.Impact of glutamatergic and serotonergic neurotransmission on diaphragm muscle activity after cervical spinal hemisection.The Challenge of Interpreting Glutamate-Receptor Ion-Channel Structures.NMDA Receptors in the Central Nervous System.Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites.Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077.Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties.

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Structural Insights into Competitive Antagonism in NMDA Receptors

http://www.wikidata.org/entity/Q27681450

description

2014 nî lūn-bûn

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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2014 թվականի հունվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Structural Insights into Competitive Antagonism in NMDA Receptors

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Structural Insights into Competitive Antagonism in NMDA Receptors

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Structural Insights into Competitive Antagonism in NMDA Receptors

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Structural Insights into Competitive Antagonism in NMDA Receptors

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Structural Insights into Competitive Antagonism in NMDA Receptors

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Structural Insights into Competitive Antagonism in NMDA Receptors

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Structural Insights into Competitive Antagonism in NMDA Receptors

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Structural Insights into Competitive Antagonism in NMDA Receptors

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Structural Insights into Competitive Antagonism in NMDA Receptors

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J.NEURON.2013.11.033

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Structural Insights into Competitive Antagonism in NMDA Receptors

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Annie Jespersen

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Ethel C Garnier-Amblard

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Gabriela Fernandez-Cuervo

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Hiro Furukawa

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Nami Tajima

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P2860

Emerging models of glutamate receptor ion channel structure and function

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

Mechanism of glutamate receptor desensitization

Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core

Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

Separation of Domain Contacts Is Required for Heterotetrameric Assembly of Functional NMDA Receptors

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

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