about
Resolution advances in cryo-EM enable application to drug discovery.A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia.All atom NMDA receptor transmembrane domain model development and simulations in lipid bilayers and water.Unravelling biological macromolecules with cryo-electron microscopy.Computationally Discovered Potentiating Role of Glycans on NMDA Receptors.Structure and symmetry inform gating principles of ionotropic glutamate receptors.A GluD Coming-Of-Age Story.Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.Supramolecular organization of NMDA receptors and the postsynaptic density.Modulating synaptic NMDA receptors.Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.Expression and Purification of the Pain Receptor TRPV1 for Spectroscopic AnalysisProbing the Structural Dynamics of the NMDA Receptor Activation by Coarse-Grained Modeling.Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain.Control of Kir channel gating by cytoplasmic domain interface interactionsThe structure-energy landscape of NMDA receptor gating.The bioactive protein-ligand conformation of GluN2C-selective positive allosteric modulators bound to the NMDA receptor.CW-EPR Spectroscopy and Site-Directed Spin Labeling to Study the Structural Dynamics of Ion Channels.Mutations of N-Methyl-D-Aspartate Receptor Subunits in Epilepsy.The Challenge of Interpreting Glutamate-Receptor Ion-Channel Structures.NMDA Receptors in the Central Nervous System.Structural Mechanisms of Gating in Ionotropic Glutamate Receptors.Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077.Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties.The LILI Motif of M3-S2 Linkers Is a Component of the NMDA Receptor Channel Gate.Activation and desensitization of ionotropic glutamate receptors by selectively triggering pre-existing motions.An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.How does binding of agonist ligands control intrinsic molecular dynamics in human NMDA receptors?A structurally derived model of subunit-dependent NMDA receptor function
P2860
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P2860
description
2016 nî lūn-bûn
@nan
2016 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Mechanism of NMDA Receptor Inhibition and Activation.
@ast
Mechanism of NMDA Receptor Inhibition and Activation.
@en
type
label
Mechanism of NMDA Receptor Inhibition and Activation.
@ast
Mechanism of NMDA Receptor Inhibition and Activation.
@en
prefLabel
Mechanism of NMDA Receptor Inhibition and Activation.
@ast
Mechanism of NMDA Receptor Inhibition and Activation.
@en
P2093
P2860
P1433
P1476
Mechanism of NMDA Receptor Inhibition and Activation.
@en
P2093
April Goehring
Chia-Hsueh Lee
Craig Yoshioka
Eric Gouaux
Hassane S Mchaourab
Richard A Stein
Shujia Zhu
P2860
P304
P356
10.1016/J.CELL.2016.03.028
P407
P577
2016-04-06T00:00:00Z