In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth
about
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malariaDiversity-oriented synthesis yields novel multistage antimalarial inhibitorsThe Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsHigh-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent MalariaThree-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.A broad analysis of resistance development in the malaria parasitePlasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.Malaria Genomics in the Era of Eradication.Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes.QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors.Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum.Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.Selection of cytochrome B mutants by putative PfNDH2 inhibitors
P2860
Q27644391-28F40BC5-BA32-4D40-AC54-1549BE750D4FQ27861934-716E69F0-5BBD-4D77-B8F0-59D430C5D721Q28066944-7206BC6B-1502-4DC1-A6A4-7BD5BA093C15Q28829342-D29ECB82-02A5-4BCE-9AC0-9269A11DFD72Q35592514-E18AE8C4-EE1A-4855-8A3A-A038C3B75072Q35892823-CE6B3634-55BD-41B7-A1D4-D1F5CB6D15E8Q36912176-17CE74A4-7690-4D1D-A48C-6A53BE28E362Q37017711-D4955B97-A69F-4D87-A2CB-2211BE27DED7Q37414137-BD9AB369-38DC-4828-81A9-9E529817B712Q38733344-1241969D-86AF-4526-874C-98CEEDDFEB5BQ38735109-5190B1CA-459E-4D37-A979-69531798D9C4Q47949539-5A26B68C-5976-46C0-A27A-C4B3FA9B2DE5Q47964175-2B41760E-4943-4646-8CA2-8F45E3C0EA3CQ48022169-4588EE75-8E85-4D45-877E-9796D8D88861Q49927350-388B4DE3-6250-4F08-8AB7-77B3C0B5DFFCQ56378245-A02B5ED3-F5FA-4EF3-A843-A24DBF607D0F
P2860
In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth
description
2014 nî lūn-bûn
@nan
2014 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
In Vitro Resistance Selections ...... inding Site and Altered Growth
@ast
In Vitro Resistance Selections ...... inding Site and Altered Growth
@en
In Vitro Resistance Selections ...... inding Site and Altered Growth
@nl
type
label
In Vitro Resistance Selections ...... inding Site and Altered Growth
@ast
In Vitro Resistance Selections ...... inding Site and Altered Growth
@en
In Vitro Resistance Selections ...... inding Site and Altered Growth
@nl
prefLabel
In Vitro Resistance Selections ...... inding Site and Altered Growth
@ast
In Vitro Resistance Selections ...... inding Site and Altered Growth
@en
In Vitro Resistance Selections ...... inding Site and Altered Growth
@nl
P2093
P2860
P921
P3181
P356
P1476
In Vitro Resistance Selections ...... inding Site and Altered Growth
@en
P2093
Francisco Javier Gamo
Leila S Ross
Maria José Lafuente-Monasterio
Onkar M P Singh
Paul Rowland
Roger C Wiegand
P2860
P304
P3181
P356
10.1074/JBC.M114.558353
P407
P50
P577
2014-06-27T00:00:00Z