Antimalarial drug discovery - approaches and progress towards new medicines.
about
Tafenoquine and its potential in the treatment and relapse prevention of Plasmodium vivax malaria: the evidence to dateOpen Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos ArylpyrrolesAsparagine requirement in Plasmodium berghei as a target to prevent malaria transmission and liver infections.In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered GrowthAnalogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivoDiversity-oriented synthesis yields novel multistage antimalarial inhibitorsA genomic and evolutionary approach reveals non-genetic drug resistance in malariaMutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone AntimalarialsApplication of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identificationA New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug DiscoveryIdentification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual ScreeningHigh-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent MalariaDiscovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate DehydrogenaseMutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug ResistanceA first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel Imidazolopiperazine KAF156 to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteers.Antimalarial compounds in Phase II clinical development.Chemical interrogation of the malaria kinome.Antimicrobial peptides: a new class of antimalarial drugs?Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum.Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growthDiversity-oriented synthesis and activity evaluation of substituted bicyclic lactams as anti-malarial against Plasmodium falciparumImaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation.Network-based gene prediction for Plasmodium falciparum malaria towards genetics-based drug discovery.Teaching old drugs new tricks to stop malaria invasion in its tracks.Discovery of Dual-Stage Malaria Inhibitors with New Targets.The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites.Ex Vivo Maturation Assay for Testing Antimalarial Sensitivity of Rodent Malaria Parasites.Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches.The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry.Current therapies and future possibilities for drug development against liver-stage malaria.In vitro evaluation of imidazo[4,5-c]quinolin-2-ones as gametocytocidal antimalarial agentsA broad analysis of resistance development in the malaria parasiteTrisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.Infection of laboratory-colonized Anopheles darlingi mosquitoes by Plasmodium vivax.Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review.From crystal to compound: structure-based antimalarial drug discovery.New insight-guided approaches to detect, cure, prevent and eliminate malaria.Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes.
P2860
Q26741307-277732B2-7D7B-46DC-B64D-AECF04862BA8Q26883657-4CAB8488-AF52-41DA-AE5D-79452F5A2436Q27319073-C5216BCB-1AD5-4928-9600-657D75D5B0DEQ27683596-00E276BB-82C7-49FF-856C-DD002404132AQ27861933-1BDD3A62-29F8-44E1-8F03-781C2228A712Q27861934-930E2951-8447-4A49-A8E1-4D61B8CEAFB6Q27861944-E71E4BFA-D3A3-4CA9-84B0-5D550DA3E9DEQ27861952-11589B8F-7ED4-45EA-99D4-249A362E793DQ28077952-EBD2792A-3822-43B7-A863-B223F30032CCQ28547546-BE72F951-3468-4DC3-BEFB-C1A526B7C194Q28548496-67D0B5A9-8DAF-40AA-AE65-ECE19415C86DQ28829342-41D09FF6-6FAC-444E-9DDB-B7D5EBA3539FQ30041606-1F540A72-46EA-4274-8F71-EAFD00C623A6Q30047024-7D5ECD50-4B0B-4283-B731-C23FF8703C95Q34434145-F9B3998D-AFF2-4424-8D99-87AC2021DC7FQ34456807-2A7A5EEA-6A56-410E-BDAC-7FE35C59DCCAQ34541909-09365A58-6A64-49F0-A998-027EBF4127A5Q34742823-2296C764-39D9-4BD1-8844-033B036B6039Q35031730-0C096BE1-28E5-4AC5-9A5D-C44D6EB1FA3AQ35140796-55E69607-5DF5-4220-8A86-0D168069652BQ35457856-DA5A94A6-F801-4D9A-943A-225CFE0E87F8Q35584827-3352E1A9-785D-4654-85C6-15307C514D1EQ35671066-18975053-5F77-4AC1-BD6A-6D3E963EA2C9Q35767057-6306CBA4-730A-4235-A807-FB4AF6F02234Q35868585-D6655507-1E49-4057-85B4-6CD6BC16D58DQ36051237-AA8C6610-1450-497F-B6C6-7DD19B4AB624Q36124336-C47727AE-E459-4B8D-A43A-0A81D38E256CQ36209383-02ECC20D-20EA-40AE-B00B-2F67530C4704Q36362906-D3A59B45-23F7-40B6-9C07-4BFD98766DA1Q36723089-E72387CF-A03F-4022-B952-CDE32EDBD98DQ36951722-FFBCF8FF-6810-4318-A7D4-C477BDDD411CQ36952275-28022FFA-087A-44B2-BDD8-4F005ADE4009Q37017711-D8583AEC-B01D-4F4E-BC68-DF84F62CE1D7Q37101499-65B7C947-7B0A-414D-AEBE-B46FF00F4DCDQ37414137-B9C362CE-5585-4E41-8FB8-C1252B455E24Q37680691-6F4B4F39-8C4E-4329-985E-519890F7E5F5Q37721293-95A0C9D2-4754-4E6D-8579-79E96A781200Q38227796-CE80D6D3-76A7-4846-B9FD-065F74EAAABFQ38260909-567C1A07-27FE-42F8-BBB8-052AC08DD939Q38735109-EF1E11D7-F146-494B-8758-5C10AEFBDE78
P2860
Antimalarial drug discovery - approaches and progress towards new medicines.
description
2013 nî lūn-bûn
@nan
2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Antimalarial drug discovery - approaches and progress towards new medicines.
@ast
Antimalarial drug discovery - approaches and progress towards new medicines.
@en
Antimalarial drug discovery - approaches and progress towards new medicines.
@nl
type
label
Antimalarial drug discovery - approaches and progress towards new medicines.
@ast
Antimalarial drug discovery - approaches and progress towards new medicines.
@en
Antimalarial drug discovery - approaches and progress towards new medicines.
@nl
prefLabel
Antimalarial drug discovery - approaches and progress towards new medicines.
@ast
Antimalarial drug discovery - approaches and progress towards new medicines.
@en
Antimalarial drug discovery - approaches and progress towards new medicines.
@nl
P2860
P3181
P356
P1476
Antimalarial drug discovery - approaches and progress towards new medicines
@en
P2093
Arnab K Chatterjee
Erika L Flannery
P2860
P2888
P304
P3181
P356
10.1038/NRMICRO3138
P407
P577
2013-11-11T00:00:00Z
P5875
P6179
1033467685