Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol - Wikidata - wikimedia - TriplyDB

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

http://www.wikidata.org/entity/Q27683648

about

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)Drugs to block cytokine signaling for the prevention and treatment of inflammation-induced preterm birth Lipopolysaccharide-induced loss of cultured rat myenteric neurons - role of AMP-activated protein kinase A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen Greensporones: resorcylic acid lactones from an aquatic Halenospora sp.TAK1 inhibitor 5Z-7-oxozeaenol sensitizes cervical cancer to doxorubicin-induced apoptosis.Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain-related molecule expression following tumor necrosis factor-α stimulation of synovial cells: an in vitro study.Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris.Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development.TGFβ activated kinase 1 (TAK1) at the crossroad of B cell receptor and Toll-like receptor 9 signaling pathways in human B cells.The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death.TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production.Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues Activation of TAK1 by MYD88 L265P drives malignant B-cell Growth in non-Hodgkin lymphoma.Regulation of Transforming Growth Factor β-Activated Kinase Activation by Epigallocatechin-3-Gallate in Rheumatoid Arthritis Synovial Fibroblasts: Suppression of K(63) -Linked Autoubiquitination of Tumor Necrosis Factor Receptor-Associated Factor 6.The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis.TAK1 selective inhibition: state of the art and future opportunities.Expression and function of transforming growth factor‑β‑activated protein kinase 1 in gastric cancer.Expression of RMRP RNA is regulated in chondrocyte hypertrophy and determines chondrogenic differentiation.Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity.Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.Transforming growth factor β activated kinase 1: a potential therapeutic target for rheumatic diseases.Rational design of resorcylic acid lactone analogues as covalent MNK1/2 kinase inhibitors by tuning the reactivity of an enamide Michael acceptor.TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis.Intra-amniotic pharmacological blockade of inflammatory signalling pathways in an ovine chorioamnionitis model.Central Administration of 5Z-7-Oxozeaenol Protects Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Microglia Activation.TAK1 inhibition in the DFG-out conformation.OM-101 Decreases the Fibrotic Response Associated with Proliferative Vitreoretinopathy.Piperidylmethyloxychalcone improves immune-mediated acute liver failure via inhibiting TAK1 activity.Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.Structure-guided development of covalent TAK1 inhibitors.An efficient synthesis of an exo-enone analogue of LL-Z1640-2 and evaluation of its protein kinase inhibitory activities.Carnosol Increases Skeletal Muscle Cell Glucose Uptake via AMPK-Dependent GLUT4 Glucose Transporter Translocation.Natural cyclopeptide RA-V inhibits the NF-κB signaling pathway by targeting TAK1.Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation

P2860

Q27684879-D31BF3EE-2E39-4C5A-8412-7965D29DD08A Q28081049-B6866502-766E-4A97-BC51-3D05B6CF236C Q28542433-E218CF86-CCC8-4328-A8CF-AF20B2AF79E8 Q28550073-22D24941-35CE-4BD7-A6A1-C4E5467CFDF3 Q28829229-B14AF052-E15E-4356-AB7D-156D69374A4D Q30840705-9F1568F2-F912-4EF9-8533-7B02E9EFE64C Q33779624-8F4E046C-696C-4DCF-B4E6-6261D9A01469 Q33861852-8C0DE832-6148-477E-8C2E-15BA20A02F8E Q34820959-F24D0A4A-C484-4BE4-B350-DE102856C7CA Q35040180-3F73C8BF-D1C0-4184-A706-076FA46E0AB3 Q35163864-74E5E5B1-E3A3-433C-A5E8-D881C615BF7E Q35685257-37819960-FD11-4D85-8D9E-4952A81E0D26 Q35818332-149C5213-10BC-40B8-9C86-0FF79B5E0158 Q35925884-F7041286-9809-48B0-9D8A-EB5A7BDD49DF Q35980393-993887FD-C506-4D07-A536-B202E74EBE10 Q36071674-F6443160-4E1B-48F6-A588-D6B69F2F2F95 Q36322487-FC87FF80-06E0-41B4-9DFC-0601E1A94E45 Q37621361-5CFE9C8C-543E-42C5-B89F-DCC45543E291 Q37740229-DCB02C45-3BB6-41C7-A23F-A3FA0AD7130E Q38289759-371DB57B-5DA7-41D2-9D08-21B5E5E0CC36 Q38315867-91358746-F746-4807-8A4A-87C51F39E2D3 Q38656687-AD51CC0C-0938-4A2B-9A5E-ABC532ADBA8D Q38661483-E75A7EBA-F569-48D7-B6C2-8189D26538E5 Q38723513-AB091ED2-D12B-46A6-9C4A-89E2095877A4 Q38751557-32C6AB13-499C-45F1-8FDA-93CB97E78771 Q38816598-1E5C75BE-BC3C-4776-8904-63C9E81C7EF1 Q38934371-8156FDCD-5DD9-42E2-ACB5-F2093AA559E7 Q39113154-50B68729-8019-4289-9892-78B608C49BF2 Q40976804-0C3B7C43-DA18-447E-AF0F-80FBC9ECA59D Q41505416-E5E3AB80-4E39-471B-B118-B3E008F7A4EB Q44526548-D1C8E86B-7508-4C10-8E37-D34610949246 Q45352917-F6342AC6-3E70-46DA-AD0D-ED3C6D5DF3EA Q45720675-B3D3460F-F856-48F3-A124-F62125A45DE8 Q47158145-1E898106-04B9-4054-96A2-E4F26473FC3E Q47935082-A99E2542-CEB3-40EA-80AA-7FA187017999 Q49726907-701D3C89-1825-422D-953D-40E60B683BF8 Q51656630-D9C0D389-5CC8-4FF6-9713-65908E7F4D85 Q53689861-CEB7B066-B2FE-4E96-8CD7-F0014D6C316B Q55352989-5204E34E-751E-4703-BACE-7A03E8730DE7 Q58601460-1D97B4F4-BDD6-4878-8AB7-CD97ADF9161F

P2860

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

http://www.wikidata.org/entity/Q27683648

description

2013 nî lūn-bûn

@nan

2013 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի մարտին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

@ast

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

@en

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

@nl

type

label

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

@ast

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

@en

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

@nl

prefLabel

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

@ast

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

@en

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

@nl

P1433

Q27683648-30BE4C2E-951F-44BC-BADD-30DBB202ACDB

P1476

Q27683648-D80BDE4D-0E2E-4EFE-8540-D7EA970050FD

P2093

Q27683648-17AED850-4186-4DB6-ABD6-7BD1E7BF32FB

Q27683648-1D6DAF7A-911E-497B-AC65-ED151344D0C1

Q27683648-1E0A80C5-EB59-492B-9530-1FC8948F5F6E

Q27683648-8E68B3CA-5836-40C3-A9BD-6DA31D981522

Q27683648-91E29400-842D-48E9-9E78-BA23D3ADEF4B

Q27683648-9F662210-E829-4796-BD93-5E780EBEA4FA

Q27683648-A3CE98E6-7D30-4E20-A851-1F8D8EC2EF5E

Q27683648-BCF92BF3-A57E-4414-B0E7-222063B37795

Q27683648-DC36F272-F4E4-49DC-8321-DE1263DC066E

Q27683648-E4C5DC0B-46A9-4CC3-90A5-8F3841FC5CF6

P304

Q27683648-E5F9A3AE-887F-46A3-8D64-51C168CBE31E

P31

Q27683648-D29D7DCC-B34C-4AB9-9DCF-4D570E76062C

P3181

Q27683648-5FD17F83-FE62-455C-B178-90E212D52231

P356

Q27683648-FF689305-7BAF-441F-98C9-D25A36EBEE79

P433

Q27683648-0C16DDED-B607-402D-8BAB-4A18F0783605

P478

Q27683648-ED80AE36-D574-4CAA-A9EE-DAA10F9DC156

P577

Q27683648-6B2BCAD6-A481-417C-BBBC-0BEEDF561D23

P698

Q27683648-608DCB00-2143-4B49-9F96-316E4B92EB3C

P921

Q27683648-B1B909B9-6FD3-43A7-BF2F-A8EC8A5B4888

P3181

P356

P1433

ACS Chemical Biology

P1476

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

@en

P2093

Dorin Toader

http://www.w3.org/2001/XMLSchema#string

Francoise Powell

http://www.w3.org/2001/XMLSchema#string

Huawei Chen

http://www.w3.org/2001/XMLSchema#string

Jamal Carlos Saeh

http://www.w3.org/2001/XMLSchema#string

Jiaquan Wu

http://www.w3.org/2001/XMLSchema#string

Jon Read

http://www.w3.org/2001/XMLSchema#string

Kate F Byth

http://www.w3.org/2001/XMLSchema#string

Mark Roth

http://www.w3.org/2001/XMLSchema#string

Nicholas A Larsen

http://www.w3.org/2001/XMLSchema#string

Rong-Fang Gu

http://www.w3.org/2001/XMLSchema#string

P304

643-50

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2463563

http://www.w3.org/2001/XMLSchema#string

P356

10.1021/CB3005897

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

8

http://www.w3.org/2001/XMLSchema#string

P577

2013-03-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23272696

http://www.w3.org/2001/XMLSchema#string

P921