Structure-guided development of covalent TAK1 inhibitors.

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Structure-guided development of covalent TAK1 inhibitors.

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2016 nî lūn-bûn

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2016年の論文

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年学术文章

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2016年學術文章

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2016年學術文章

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Structure-guided development of covalent TAK1 inhibitors.

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Structure-guided development of covalent TAK1 inhibitors.

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label

Structure-guided development of covalent TAK1 inhibitors.

@en

Structure-guided development of covalent TAK1 inhibitors.

@nl

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Structure-guided development of covalent TAK1 inhibitors.

@en

Structure-guided development of covalent TAK1 inhibitors.

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P1476

Structure-guided development of covalent TAK1 inhibitors.

@en

P2093

Chun-Pong Tam

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Douglas S Jones

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Ellen L Weisberg

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Guangyan Du

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James D Griffin

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Jarrod A Marto

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John C Hunter

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Nathanael S Gray

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Samar Mowafy

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Scott B Ficarro

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P2860

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Developing irreversible inhibitors of the protein kinase cysteinome

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol

Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)

Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics

5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner

P304

838-846

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P31

scholarly article

P356

10.1016/J.BMC.2016.11.035

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P407

English

P433

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P478

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P50

P577

2016-12-09T00:00:00Z

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P698

28011204

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P932

5484537

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