2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance
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4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase InhibitorsHepatitis B virus replication is blocked by a 2-hydroxyisoquinoline-1,3(2H,4H)-dione (HID) inhibitor of the viral ribonuclease H activityDesign, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities.Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.Progress in HIV-1 Integrase Inhibitors: A Review of their Chemical Structure Diversity.Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.The preclinical discovery and development of dolutegravir for the treatment of HIV.Inhibition of hepatitis B virus replication by N-hydroxyisoquinolinediones and related polyoxygenated heterocycles.
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P2860
2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance
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2-Hydroxyisoquinoline-1,3(2H,4 ...... h a high barrier to resistance
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2-Hydroxyisoquinoline-1,3(2H,4 ...... h a high barrier to resistance
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2-Hydroxyisoquinoline-1,3(2H,4 ...... h a high barrier to resistance
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2-Hydroxyisoquinoline-1,3(2H,4 ...... h a high barrier to resistance
@ast
2-Hydroxyisoquinoline-1,3(2H,4 ...... h a high barrier to resistance
@en
2-Hydroxyisoquinoline-1,3(2H,4 ...... h a high barrier to resistance
@nl
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2-Hydroxyisoquinoline-1,3(2H,4 ...... h a high barrier to resistance
@ast
2-Hydroxyisoquinoline-1,3(2H,4 ...... h a high barrier to resistance
@en
2-Hydroxyisoquinoline-1,3(2H,4 ...... h a high barrier to resistance
@nl
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P50
P3181
P356
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2-Hydroxyisoquinoline-1,3(2H,4 ...... h a high barrier to resistance
@en
P2093
Frauke Christ
Oliver Taltynov
Philippe Cotelle
Sergei V Strelkov
Virginie Suchaud
P304
P3181
P356
10.1021/CB4000426
P577
2013-04-02T00:00:00Z