Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.
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4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant IntegrasesSelectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.Drug resistant integrase mutants cause aberrant HIV integrations.1,8-Naphthyridine Derivatives: A Review of Multiple Biological Activities.Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives.Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors.Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.Ligand-controlled gold-catalyzed cycloisomerization of 1,n-enyne esters toward synthesis of dihydronaphthalene.Developing and evaluating inhibitors against the RNase H active site of HIV-1 RT.Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants.Recent advances in the discovery of small-molecule inhibitors of HIV-1 integrase
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Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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Bicyclic 1-hydroxy-2-oxo-1,2-d ...... r-resistant integrase mutants.
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Bicyclic 1-hydroxy-2-oxo-1,2-d ...... r-resistant integrase mutants.
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type
label
Bicyclic 1-hydroxy-2-oxo-1,2-d ...... r-resistant integrase mutants.
@en
Bicyclic 1-hydroxy-2-oxo-1,2-d ...... r-resistant integrase mutants.
@nl
prefLabel
Bicyclic 1-hydroxy-2-oxo-1,2-d ...... r-resistant integrase mutants.
@en
Bicyclic 1-hydroxy-2-oxo-1,2-d ...... r-resistant integrase mutants.
@nl
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Bicyclic 1-hydroxy-2-oxo-1,2-d ...... r-resistant integrase mutants.
@en
P2093
Barry C Johnson
Christophe Marchand
Mathieu Métifiot
Steven J Smith
Terrence R Burke
Xue Zhi Zhao
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P304
P356
10.1021/JM401902N
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P577
2014-02-10T00:00:00Z