β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease
about
Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugsExpanding opportunities for mining bioactive chemistry from patentsThe Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and OpportunitiesBiomarkers in Alzheimer's disease analysis by mass spectrometry-based proteomicsA tale of two drug targets: the evolutionary history of BACE1 and BACE2Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsCyanogen BromideSeamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors.Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseElectroacupuncture Reduces Aβ Production and BACE1 Expression in SAMP8 Mice.1,3-Oxazines as BACE1 and/or BACE2 inhibitors: a patent evaluation (WO2012156284).Current pharmacotherapy and putative disease-modifying therapy for Alzheimer's disease.Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal.Computational analysis of BACE1-ligand complex crystal structures and linear discriminant analysis for identification of BACE1 inhibitors with anti P-glycoprotein binding property.Molecular docking of fisetin with AD associated AChE, ABAD and BACE1 proteins.In silico repurposing of antipsychotic drugs for Alzheimer's disease.Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.Constant pH Molecular Dynamics Reveals pH-Modulated Binding of Two Small-Molecule BACE1 Inhibitors.Fragment-based virtual screening approach and molecular dynamics simulation studies for identification of BACE1 inhibitor leads.Synthesis of amino heterocycle aspartyl protease inhibitors.Catalytic Asymmetric 1,3-Dipolar Cycloaddition of β-Fluoroalkylated α,β-Unsaturated 2-Pyridylsulfones with Nitrones for Chiral Fluoroalkylated Isoxazolidines and γ-Amino Alcohols.Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.
P2860
Q26740189-1B5E432C-E839-49D5-AAE3-5B6661CB525FQ26801615-A43EFFB9-312E-4B61-9FAF-B3F4FE3DF2B4Q27014740-7261B06A-984E-4F64-8D84-25D1B1E7B9B3Q27024518-E21F93B4-79D2-4394-8A0B-DE11F46AB1CDQ28661086-9BA96DC4-2F4C-4A36-AD81-A345DD03F039Q28822108-64AB7196-2F11-44B2-853F-B1516F51805DQ29036692-BB2473D5-C085-4D26-9A75-3B69AFAE6058Q30741444-44A6E712-5463-4289-AB18-8D27F085F148Q34091134-9DE2576B-397B-4318-B902-D7CC7A575235Q34156758-854D1100-C847-497D-AEF0-04D72ADB8BCEQ35898132-F6C4B4AF-961E-4F31-88D3-22C3A55F986AQ38120306-634D03F4-122C-45BC-9208-FFC7B26CC3A4Q38850493-7A38BAAA-14D6-44C5-9492-5818422878D3Q38994300-27C2C6D8-E27A-40D8-940D-CAF760E781A5Q39024147-E42B52A7-C1FB-452A-9B45-00CC5598EC1DQ42190615-EA083BED-C83C-4001-8876-6B304583575BQ42610044-8B11A8EA-BADF-40B0-9A18-737C139EE2C3Q46134175-FA88BDF2-9146-403E-8FD2-6EF6EBC44953Q47136224-42A2B5C8-5BC4-4840-AEF7-DFAB8ADC8A6EQ48059653-EE93C60F-E185-42C4-8DEA-2DFE2E937661Q50856369-E5BCF757-040B-452C-9C9E-E3B6409B8A21Q51054941-A91255C1-3A50-438A-9003-DD073DA8765AQ54940167-0F2A6112-D49D-4F22-820B-6AD2ABF4899F
P2860
β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease
description
2013 nî lūn-bûn
@nan
2013 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
β-Secretase (BACE1) inhibitors ...... luation in Alzheimer's disease
@ast
β-Secretase (BACE1) inhibitors ...... luation in Alzheimer's disease
@en
β-Secretase (BACE1) inhibitors ...... luation in Alzheimer's disease
@nl
type
label
β-Secretase (BACE1) inhibitors ...... luation in Alzheimer's disease
@ast
β-Secretase (BACE1) inhibitors ...... luation in Alzheimer's disease
@en
β-Secretase (BACE1) inhibitors ...... luation in Alzheimer's disease
@nl
prefLabel
β-Secretase (BACE1) inhibitors ...... luation in Alzheimer's disease
@ast
β-Secretase (BACE1) inhibitors ...... luation in Alzheimer's disease
@en
β-Secretase (BACE1) inhibitors ...... luation in Alzheimer's disease
@nl
P2093
P3181
P356
P1476
β-Secretase (BACE1) inhibitors ...... luation in Alzheimer's disease
@en
P2093
Alessandra Bergadano
Alessandra Polara
Alexander V Mayweg
Christian Schnider
Daniela Krummenacher
David W Banner
Emmanuel Pinard
Hans Hilpert
Harald Mauser
Helmut Jacobsen
P304
P3181
P356
10.1021/JM400225M
P407
P577
2013-05-23T00:00:00Z