Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design
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Targeting the Pim kinases in multiple myelomaStructure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase InhibitorsTargeting Pim kinases for cancer treatment: opportunities and challengesInsulin receptor substrate 1 is a substrate of the Pim protein kinases.Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing.Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.Metal-free direct alkylation of unfunctionalized allylic/benzylic sp3 C-H bonds via photoredox induced radical cation deprotonation.Pim Kinase Inhibitors Evaluated with a Single-Molecule Engineered Nanopore Sensor.
P2860
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P2860
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Discovery of novel pyrazolo[1, ...... and property-based drug design
@ast
Discovery of novel pyrazolo[1, ...... and property-based drug design
@en
Discovery of novel pyrazolo[1, ...... and property-based drug design
@nl
type
label
Discovery of novel pyrazolo[1, ...... and property-based drug design
@ast
Discovery of novel pyrazolo[1, ...... and property-based drug design
@en
Discovery of novel pyrazolo[1, ...... and property-based drug design
@nl
prefLabel
Discovery of novel pyrazolo[1, ...... and property-based drug design
@ast
Discovery of novel pyrazolo[1, ...... and property-based drug design
@en
Discovery of novel pyrazolo[1, ...... and property-based drug design
@nl
P2093
P1476
Discovery of novel pyrazolo[1, ...... and property-based drug design
@en
P2093
Allen J Ebens
Eric Harstad
Grace Chan
Heidi Wallweber
Huiyong Hu
Jason Drummond
Jeremy Murray
John Moffat
Rich Pastor
P304
P356
10.1016/J.BMCL.2013.04.020
P407
P577
2013-06-01T00:00:00Z