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Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritisStructural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of ComplementMechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signalingIdentification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitorsAllosteric peptides bind a caspase zymogen and mediate caspase tetramerizationStructure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug designDesign and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitorsTailoring small molecules for an allosteric site on procaspase-6An allosteric switch for pro-HGF/Met signaling using zymogen activator peptidesStructure of C3b in complex with CRIg gives insights into regulation of complement activationATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetasesCharacterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Micah Steffek
@ast
Micah Steffek
@en
Micah Steffek
@es
Micah Steffek
@nl
Micah Steffek
@sl
type
label
Micah Steffek
@ast
Micah Steffek
@en
Micah Steffek
@es
Micah Steffek
@nl
Micah Steffek
@sl
prefLabel
Micah Steffek
@ast
Micah Steffek
@en
Micah Steffek
@es
Micah Steffek
@nl
Micah Steffek
@sl