The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism - Wikidata - wikimedia - TriplyDB

The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

http://www.wikidata.org/entity/Q27684737

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ROR nuclear receptors: structures, related diseases, and drug discovery Ivermectin - Old Drug, New Tricks?An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes Recent advances in the understanding and management of rosacea.The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer.Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor.Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease.Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor Targeting nuclear receptors with marine natural products.Topical ivermectin improves allergic skin inflammation.Inhibition of Plasmodium Liver Infection by Ivermectin.Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.On the relationship of anthranilic derivatives structure and the FXR (Farnesoid X receptor) agonist activity.Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ -independent manner and an amino acid residue at the slide helix governs the activation.Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers.Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.Discovery of new non-steroidal farnesoid X receptor modulators through 3D shape similarity search and structure-based virtual screening.Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening.Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR

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The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

http://www.wikidata.org/entity/Q27684737

description

2013 nî lūn-bûn

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2013 թուականին հրատարակուած գիտական յօդուած

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2013 թվականին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

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The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

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The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

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The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

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The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

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The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

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The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

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The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

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The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

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Nature Communications

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The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism

@en

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Hongyan Liu

http://www.w3.org/2001/XMLSchema#string

Hui Rong

http://www.w3.org/2001/XMLSchema#string

Lihua Jin

http://www.w3.org/2001/XMLSchema#string

Lin Qiu

http://www.w3.org/2001/XMLSchema#string

Rui Wang

http://www.w3.org/2001/XMLSchema#string

Shanshan Wang

http://www.w3.org/2001/XMLSchema#string

Shengchen Lin

http://www.w3.org/2001/XMLSchema#string

Song Li

http://www.w3.org/2001/XMLSchema#string

Weili Zheng

http://www.w3.org/2001/XMLSchema#string

Wen Xie

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of a nuclear receptor for bile acids

Bile acids: natural ligands for an orphan nuclear receptor

Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

Processing of X-ray diffraction data collected in oscillation mode

Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors

A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR

Structural basis for bile acid binding and activation of the nuclear receptor FXR

FXR agonist activity of conformationally constrained analogs of GW 4064

Principles of activation and permeation in an anion-selective Cys-loop receptor

Revealing a steroid receptor ligand as a unique PPARγ agonist

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1937

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10.1038/NCOMMS2924

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4

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2013-01-01T00:00:00Z

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237004697

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1043683656

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23728580

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