FXR agonist activity of conformationally constrained analogs of GW 4064 - Wikidata - wikimedia - TriplyDB

FXR agonist activity of conformationally constrained analogs of GW 4064

FXR agonist activity of conformationally constrained analogs of GW 4064

http://www.wikidata.org/entity/Q27656341

about

The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation.Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.Pharmacophore-based discovery of FXR-agonists. Part II: identification of bioactive triterpenes from Ganoderma lucidum Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease.Structural Investigation for Optimization of Anthranilic Acid Derivatives as Partial FXR Agonists by in Silico Approaches.Farnesoid X receptor modulators: a patent review.Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators.Nuclear receptor control of enterohepatic circulation.Characterizing ligands for farnesoid X receptor--available in vitro test systems for farnesoid X receptor modulator development.Combining self- and cross-docking as benchmark tools: the performance of DockBench in the D3R Grand Challenge 2.Performance of HADDOCK and a simple contact-based protein-ligand binding affinity predictor in the D3R Grand Challenge 2.Role of farnesoid X receptor in cholestasis.Structure-activity relationship studies of indole-based compounds as small molecule HIV-1 fusion inhibitors targeting glycoprotein 41.Antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription.Simultaneous diastereo- and enantioseparation of farnesoid X receptor (FXR) agonists with a quinine carbamate-based chiral stationary phase.Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin.Using physics-based pose predictions and free energy perturbation calculations to predict binding poses and relative binding affinities for FXR ligands in the D3R Grand Challenge 2.A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly.

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P2860

FXR agonist activity of conformationally constrained analogs of GW 4064

http://www.wikidata.org/entity/Q27656341

description

2009 nî lūn-bûn

@nan

2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի օգոստոսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

FXR agonist activity of conformationally constrained analogs of GW 4064

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FXR agonist activity of conformationally constrained analogs of GW 4064

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FXR agonist activity of conformationally constrained analogs of GW 4064

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type

label

FXR agonist activity of conformationally constrained analogs of GW 4064

@ast

FXR agonist activity of conformationally constrained analogs of GW 4064

@en

FXR agonist activity of conformationally constrained analogs of GW 4064

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prefLabel

FXR agonist activity of conformationally constrained analogs of GW 4064

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FXR agonist activity of conformationally constrained analogs of GW 4064

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FXR agonist activity of conformationally constrained analogs of GW 4064

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J.BMCL.2009.06.062

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Bioorganic & Medicinal Chemistry Letters

P1476

FXR agonist activity of conformationally constrained analogs of GW 4064

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P2093

Aaron B Miller

http://www.w3.org/2001/XMLSchema#string

Adwoa Akwabi-Ameyaw

http://www.w3.org/2001/XMLSchema#string

Dan Todd

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David N Deaton

http://www.w3.org/2001/XMLSchema#string

Derek J Parks

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Frank Navas

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G Bruce Wisely

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Harry B Marr

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Jonathan Y Bass

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Justin A Caravella

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4733-4739

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scholarly article

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2409976

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10.1016/J.BMCL.2009.06.062

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16

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2009-06-21T00:00:00Z

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19586769

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