Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5
about
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondinControl of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in CancerIn a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR FamilyStructural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondinStructures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for SignalingN-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding AbilityCrystal structure of LGR4-Rspo1 complex: insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs).Intrinsic disorder in spondins and some of their interacting partners.Updating the Wnt pathways.Engineering high-potency R-spondin adult stem cell growth factors.LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli.Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis.The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strengthStructure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells.Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells.Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms.Generation and characterization of monoclonal antibodies against human LGR6.RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer.Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewalR-spondins can potentiate WNT signaling without LGRs.Probing Wnt Receptor Turnover: A Critical Regulatory Point of Wnt Pathway.Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer
P2860
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P2860
Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
name
Structure of stem cell growth ...... ctodomain of its receptor LGR5
@ast
Structure of stem cell growth ...... ctodomain of its receptor LGR5
@en
Structure of stem cell growth ...... ctodomain of its receptor LGR5
@nl
type
label
Structure of stem cell growth ...... ctodomain of its receptor LGR5
@ast
Structure of stem cell growth ...... ctodomain of its receptor LGR5
@en
Structure of stem cell growth ...... ctodomain of its receptor LGR5
@nl
prefLabel
Structure of stem cell growth ...... ctodomain of its receptor LGR5
@ast
Structure of stem cell growth ...... ctodomain of its receptor LGR5
@en
Structure of stem cell growth ...... ctodomain of its receptor LGR5
@nl
P2093
P50
P3181
P1433
P1476
Structure of stem cell growth ...... ctodomain of its receptor LGR5
@en
P2093
Joke C M Granneman
Meritxell Huch
Weng Chuan Peng
Wim de Lau
P304
P3181
P356
10.1016/J.CELREP.2013.06.009
P577
2013-06-27T00:00:00Z