%D9%87%D8%A7%D9%86%D8%B3_%DA%A9%D9%88%D9%84%D8%B1%D8%B2Category:Hans_CleversHans_CleversHans_Clevers%E3%83%8F%E3%83%B3%E3%82%B9%E3%83%BB%E3%82%AF%E3%83%AC%E3%83%B4%E3%82%A1%E3%83%BC%E3%82%B9Hans_CleversHans_Clevers%D0%9A%D0%BB%D0%B5%D0%B2%D0%B5%D1%80%D1%81,_%D0%A5%D0%B0%D0%BD%D1%81%D0%93%D0%B0%D0%BD%D1%81_%D0%9A%D0%BB%D0%B5%D0%B2%D0%B5%D1%80%D1%81Q1579050
about
The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesisWhat does the concept of the stem cell niche really mean today?Inflammatory Bowel Disease, Stress, and the Endoplasmic ReticulumRap2A links intestinal cell polarity to brush border formationTumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsCloning and characterization of hELD/OSA1, a novel BRG1 interacting proteinThe inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleusLoss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of DvlIntestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like propertiesLgr5 homologues associate with Wnt receptors and mediate R-spondin signallingThe beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cellsThe kinase TNIK is an essential activator of Wnt target genesA positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placentaIllegitimate WNT signaling promotes proliferation of multiple myeloma cellsActomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growthThe cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic miceSingle-cell dissection of transcriptional heterogeneity in human colon tumorsWnt signaling, lgr5, and stem cells in the intestine and skinModeling Development and Disease with OrganoidsWnt/β-catenin signaling and diseaseAdult mammalian stem cells: the role of Wnt, Lgr5 and R-spondinsGeneration of BAC transgenic epithelial organoidsA comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal cryptStructures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for SignalingStructure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5Wnt/beta-catenin signaling in development and diseaseIdentification of stem cells in small intestine and colon by marker gene Lgr5Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitmentOrigins of lymphatic and distant metastases in human colorectal cancer.Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.Regulation and plasticity of intestinal stem cells during homeostasis and regeneration.Translational applications of adult stem cell-derived organoids.Oncogene-inducible organoids as a miniature platform to assess cancer characteristics.Lineage-dependent spatial and functional organization of the mammalian enteric nervous system.Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels.Long-term expanding human airway organoids for disease modelingAn FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistanceCancer modeling meets human organoid technologyNotch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche
P50
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P50
description
Nederlands moleculair bioloog
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niederländischer Immunologe und Molekulargenetiker
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Hans Clevers
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Hans Clevers
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Hans Clevers
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Ганс Клеверс
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Ганс Клеверс
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