Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives

Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives

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http://www.wikidata.org/entity/Q27685316
Other targeted drugs in melanomaThe rational design of specific peptide inhibitor against p38α MAPK at allosteric-site: a therapeutic modality for HNSCCExploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.Studies on [5,6]-Fused Bicyclic Scaffolds Derivatives as Potent Dual B-RafV600E/KDR Inhibitors Using Docking and 3D-QSAR Approaches.Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing.Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance.An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling.Computational study on the unbinding pathways of B-RAF inhibitors and its implication for the difference of residence time: insight from random acceleration and steered molecular dynamics simulations.BRAF signals to pro-apoptotic BIM to enhance AraC cytotoxicity induced in AML cells by Vitamin D-based differentiation agents.New perspectives for targeting RAF kinase in human cancer.Energetics and structural characterization of the "DFG-flip" conformational transition of B-RAF kinase: a SITS molecular dynamics study.A modified gene trap approach for improved high-throughput cancer drug discovery.Development of small-molecule therapeutics and strategies for targeting RAF kinase in BRAF-mutant colorectal cancer
P2860

Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives

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http://www.wikidata.org/entity/Q27685316
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2013 nî lūn-bûn
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2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
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2013 թվականի օգոստոսին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年學術文章
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Discovery of a selective kinas ...... 1,3-benzothiazole derivatives
@ast
Discovery of a selective kinas ...... 1,3-benzothiazole derivatives
@en
Discovery of a selective kinas ...... 1,3-benzothiazole derivatives
@nl
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label
Discovery of a selective kinas ...... 1,3-benzothiazole derivatives
@ast
Discovery of a selective kinas ...... 1,3-benzothiazole derivatives
@en
Discovery of a selective kinas ...... 1,3-benzothiazole derivatives
@nl
prefLabel
Discovery of a selective kinas ...... 1,3-benzothiazole derivatives
@ast
Discovery of a selective kinas ...... 1,3-benzothiazole derivatives
@en
Discovery of a selective kinas ...... 1,3-benzothiazole derivatives
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Discovery of a selective kinas ...... 1,3-benzothiazole derivatives
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698