Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents
about
Recent contributions of structure-based drug design to the development of antibacterial compounds.A novel high-throughput cell-based assay aimed at identifying inhibitors of DNA metabolism in bacteriaSynthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivativesRepurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.Inactivation of multiple bacterial histidine kinases by targeting the ATP-binding domain.A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design.New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development.Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an InhibitorEscherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy.Design, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors.Synthesis and Evaluation of N-Phenylpyrrolamides as DNA Gyrase B Inhibitors.Design, Synthesis, and Evaluation of Novel Tyrosine-Based DNA Gyrase B Inhibitors.Backbone assignment of the N-terminal 24-kDa fragment of Escherichia coli topoisomerase IV ParE subunit.Supramolecular pyridyl urea gels as soft matter with antibacterial properties against MRSA and/or E. coli.NMR structural characterization of the N-terminal active domain of the gyrase B subunit fromPseudomonas aeruginosaand its complex with an inhibitorNew N-phenylpyrrolamide DNA gyrase B inhibitors: Optimization of efficacy and antibacterial activity
P2860
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P2860
Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Fragment-to-hit-to-lead discov ...... nhibiting antibacterial agents
@ast
Fragment-to-hit-to-lead discov ...... nhibiting antibacterial agents
@en
Fragment-to-hit-to-lead discov ...... nhibiting antibacterial agents
@nl
type
label
Fragment-to-hit-to-lead discov ...... nhibiting antibacterial agents
@ast
Fragment-to-hit-to-lead discov ...... nhibiting antibacterial agents
@en
Fragment-to-hit-to-lead discov ...... nhibiting antibacterial agents
@nl
prefLabel
Fragment-to-hit-to-lead discov ...... nhibiting antibacterial agents
@ast
Fragment-to-hit-to-lead discov ...... nhibiting antibacterial agents
@en
Fragment-to-hit-to-lead discov ...... nhibiting antibacterial agents
@nl
P2093
P356
P1476
Fragment-to-hit-to-lead discov ...... nhibiting antibacterial agents
@en
P2093
Ann E Eakin
Brian A Sherer
Brian Dangel
Gregory S Basarab
John I Manchester
Maria Uria-Nickelsen
P Ann Boriack-Sjodin
Ruth Illingworth
Shanta Bist
Shubha Sriram
P304
P356
10.1021/JM401208B
P407
P577
2013-11-14T00:00:00Z