Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
about
Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90Endless Resistance. Endless Antibiotics?Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolonesThiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyraseAnti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens.New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development.Genetic Resistance Determinants, In Vitro Time-Kill Curve Analysis and Pharmacodynamic Functions for the Novel Topoisomerase II Inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeaeEfficacy of a Novel Tricyclic Topoisomerase Inhibitor in a Murine Model of Neisseria gonorrhoeae InfectionAntimicrobial-resistant sexually transmitted infections: gonorrhoea and Mycoplasma genitalium.Targeting bacterial topoisomerases: how to counter mechanisms of resistance.Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.Recent Advances in the Rational Design and Optimization of Antibacterial Agents.What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles.Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.Absorption, distribution, metabolism and elimination of 14C-ETX0914, a novel inhibitor of bacterial type-II topoisomerases in rodents.Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site.Understanding drug resistance will improve the treatment of bacterial infections.Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria.Expedient synthesis of tetrahydroquinoline-3-spirohydantoin derivatives via the Lewis acid-catalyzed tert-amino effect reaction.
P2860
Q26997981-3401A324-D920-45B6-8AB0-36BC24C1D256Q28822179-D2260689-36A7-46B4-B0C9-EF98E6B908B2Q28828291-8E03904E-A7E6-4089-9F26-78B2D031F3D0Q33782498-EC32A334-992B-468A-A5B4-31CC43B952D4Q36006797-EE630705-AE91-44DE-B8F6-F6E53C606E0DQ36153263-09965F89-0B60-4F0F-9521-8C58735C5925Q36360329-E611BFE0-8707-4EAF-833C-03ACBC7382EEQ37203757-E042752E-81E0-47BB-AF05-C29818032B3AQ38772340-A1B56D06-96B9-4E4C-B4F1-CEDF36A25303Q38855273-B3C8D6C5-8012-41A5-996E-414EEDD3DB06Q38949284-98A80CAF-3C27-466A-8459-3BD19ADB7B6AQ38958278-8CA6971B-575A-4941-B1DF-BE2B58458D26Q39120027-49EC6CC3-D093-47BA-949E-3235D5771DA4Q40239631-88315099-605F-45A0-867F-D31C46B2EF6FQ40696170-5F0811B3-CF4F-4CC6-BCD7-9DBE23425FE2Q48105075-9DFF9CBC-03FA-4132-BC75-2ADBF1C0BDD8Q50095987-BD4FE8C4-5E3B-4BB3-B74C-A0911B561F9DQ53687829-B7ACDFDD-0849-406C-AFCE-E4E55CBA6B49Q54573145-39251AEA-DEA8-41EB-B806-861C25701EAE
P2860
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Responding to the challenge of ...... terial Type II topoisomerases.
@ast
Responding to the challenge of ...... terial Type II topoisomerases.
@en
type
label
Responding to the challenge of ...... terial Type II topoisomerases.
@ast
Responding to the challenge of ...... terial Type II topoisomerases.
@en
prefLabel
Responding to the challenge of ...... terial Type II topoisomerases.
@ast
Responding to the challenge of ...... terial Type II topoisomerases.
@en
P2093
P2860
P356
P1433
P1476
Responding to the challenge of ...... cterial Type II topoisomerases
@en
P2093
Amy Kimzey
Amy Kutschke
Grant Walkup
Gregory S Basarab
Gunther H Kern
Humphrey Gardner
John McNulty
John P Mueller
Joseph V Newman
Karthick Vishwanathan
P2860
P2888
P356
10.1038/SREP11827
P407
P577
2015-07-14T00:00:00Z