Crystal structure of an HSA/FcRn complex reveals recycling by competitive mimicry of HSA ligands at a pH-dependent hydrophobic interface
about
Albumin-based drug delivery: harnessing nature to cure diseaseUnraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based TherapeuticsStructural Insights into Neonatal Fc Receptor-based Recycling MechanismsThe neonatal Fc receptor, FcRn, as a target for drug delivery and therapySite-specific albumination of a therapeutic protein with multi-subunit to prolong activity in vivoHepatic FcRn regulates albumin homeostasis and susceptibility to liver injuryExtending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.Albuminoid genes: evolving at the interface of dispensability and selectionpH-dependent binding engineering reveals an FcRn affinity threshold that governs IgG recycling.FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.Molecular Analysis of AFP and HSA Interactions with PTEN Protein.Mechanism of increased clearance of glycated albumin by proximal tubule cells.Albumin and its application in drug delivery.Receptor-Mediated Endocytosis in the Proximal Tubule.Intrinsically Disordered Regions in Serum Albumin: What Are They For?Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodiesInteraction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn).Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.Structural basis for alpha fetoprotein-mediated inhibition of caspase-3 activity in hepatocellular carcinoma cells.Conservation of sequence motifs suggests that the nonclassical MHC class I lineages CD1/PROCR and UT were established before the emergence of tetrapod species.Human and mouse albumin bind their respective neonatal Fc receptors differently
P2860
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P2860
Crystal structure of an HSA/FcRn complex reveals recycling by competitive mimicry of HSA ligands at a pH-dependent hydrophobic interface
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Crystal structure of an HSA/Fc ...... ependent hydrophobic interface
@ast
Crystal structure of an HSA/Fc ...... ependent hydrophobic interface
@en
Crystal structure of an HSA/Fc ...... ependent hydrophobic interface
@nl
type
label
Crystal structure of an HSA/Fc ...... ependent hydrophobic interface
@ast
Crystal structure of an HSA/Fc ...... ependent hydrophobic interface
@en
Crystal structure of an HSA/Fc ...... ependent hydrophobic interface
@nl
prefLabel
Crystal structure of an HSA/Fc ...... ependent hydrophobic interface
@ast
Crystal structure of an HSA/Fc ...... ependent hydrophobic interface
@en
Crystal structure of an HSA/Fc ...... ependent hydrophobic interface
@nl
P2093
P1433
P1476
Crystal structure of an HSA/Fc ...... ependent hydrophobic interface
@en
P2093
Alec J Murillo
Alison W Tisdale
Allyson L Masci
Amy J Andreucci
Bracken M King
Christian Dombrowski
David V Erbe
Emily B Schirmer
Eric S Furfine
Joseph T Kovalchin
P304
P356
10.1016/J.STR.2013.08.022
P577
2013-11-05T00:00:00Z