Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms - Wikidata - wikimedia - TriplyDB

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

http://www.wikidata.org/entity/Q27681475

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Albumin-based drug delivery: harnessing nature to cure disease TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity Human IgG4: a structural perspective A perspective on the structure and receptor binding properties of immunoglobulin G Fc Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab Targeting FcRn for the modulation of antibody dynamics The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding.Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry pH-dependent binding engineering reveals an FcRn affinity threshold that governs IgG recycling.FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties.A novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life.Cross-Sectional Guidelines for Therapy with Blood Components and Plasma Derivatives: Chapter 5 Human Albumin - Revised Cross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor.Albumin and its application in drug delivery.Structural analysis of Fc/FcγR complexes: a blueprint for antibody design.The multiple facets of FcRn in immunity.Direct demonstration of a neonatal Fc receptor (FcRn)-driven endosomal sorting pathway for cellular recycling of albumin.Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation.TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity Intrinsically Disordered Regions in Serum Albumin: What Are They For?Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life.Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies.An antidote approach to reduce risk and broaden utility of antibody-based therapeutics.Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life.Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions.Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn).Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor.Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy.Human Neonatal Fc Receptor as a New Potential Antibody Binding Protein for Antibody Immobilisation.An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications.Structural characterization of the Man5 glycoform of human IgG3 Fc.IgG Fc engineering to modulate antibody effector functions.Ocular delivery of proteins and peptides: challenges and novel formulation approaches.

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

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2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

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JBC.M113.537563

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Journal of Biological Chemistry

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

@en

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Changshou Gao

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Herren Wu

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Kimberly E Cook

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Melissa M Damschroder

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Qing Li

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William F Dall'Acqua

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P2860

The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystal structure of human serum albumin at 2.5 A resolution

Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

Structural characterization of a human Fc fragment engineered for extended serum half-life

Crystal structure of an HSA/FcRn complex reveals recycling by competitive mimicry of HSA ligands at a pH-dependent hydrophobic interface

Crystal structure of the complex of rat neonatal Fc receptor with Fc

Structural basis of pH-dependent antibody binding by the neonatal Fc receptor

Likelihood-enhanced fast translation functions

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7812-24

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4767520

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10.1074/JBC.M113.537563

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11

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289

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Vaheh Oganesyan

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2014-03-14T00:00:00Z

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24469444

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3953293

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