Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism
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Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode ClassificationChemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitorsThe sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemiaSelective Sirt2 inhibition by ligand-induced rearrangement of the active site.Selectivity hot-spots of sirtuin catalytic cores.Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrolUsing mitochondrial sirtuins as drug targets: disease implications and available compounds.New assays and approaches for discovery and design of Sirtuin modulators.Mitochondrial Sirtuins in Cancer: Emerging Roles and Therapeutic Potential.Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria.The Role of Sirtuins in Antioxidant and Redox Signaling.Therapeutic Versatility of Resveratrol Derivatives.2-Methoxyestradiol Affects Mitochondrial Biogenesis Pathway and Succinate Dehydrogenase Complex Flavoprotein Subunit A in Osteosarcoma Cancer Cells.Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors
P2860
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P2860
Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism
description
2013 nî lūn-bûn
@nan
2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Crystal structures of Sirt3 co ...... sites and inhibition mechanism
@ast
Crystal structures of Sirt3 co ...... sites and inhibition mechanism
@en
Crystal structures of Sirt3 co ...... sites and inhibition mechanism
@nl
type
label
Crystal structures of Sirt3 co ...... sites and inhibition mechanism
@ast
Crystal structures of Sirt3 co ...... sites and inhibition mechanism
@en
Crystal structures of Sirt3 co ...... sites and inhibition mechanism
@nl
prefLabel
Crystal structures of Sirt3 co ...... sites and inhibition mechanism
@ast
Crystal structures of Sirt3 co ...... sites and inhibition mechanism
@en
Crystal structures of Sirt3 co ...... sites and inhibition mechanism
@nl
P50
P1476
Crystal structures of Sirt3 co ...... sites and inhibition mechanism
@en
P304
P356
10.1016/J.CHEMBIOL.2013.09.019
P577
2013-11-21T00:00:00Z