Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma.
about
Shortcomings in the current treatment of epilepsyIdentification of new epilepsy treatments: issues in preclinical methodologyTargeted Treatment in Childhood Epilepsy SyndromesNovel frontiers in epilepsy treatments: preventing epileptogenesis by targeting inflammationPreclinical antiepileptic actions of selective serotonin reuptake inhibitors--implications for clinical trial designCurrent prospects and challenges for epilepsy gene therapyModulation of antioxidant enzymatic activities by certain antiepileptic drugs (valproic acid, oxcarbazepine, and topiramate): evidence in humans and experimental modelsNew vistas on astroglia in convulsive and non-convulsive epilepsy highlight novel astrocytic targets for treatmentPharmacoresistant epilepsy: unmet needs in solving the puzzle(s)Anti-epileptogenic clinical trial designs in epilepsy: issues and optionsSeizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterizationA smell that causes seizureCritical Evaluation of P2X7 Receptor Antagonists in Selected Seizure ModelsChanging channels in pain and epilepsy: Exploiting ion channel gene therapy for disorders of neuronal hyperexcitabilityInsights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsyNew in vitro phenotypic assay for epilepsy: fluorescent measurement of synchronized neuronal calcium oscillationsThirty Years of Orphan Drug Legislation and the Development of Drugs to Treat Rare Seizure Conditions: A Cross Sectional AnalysisControl of in vivo ictogenesis via endogenous synaptic pathways.A swell in the armamentarium of antiepileptic drug targetsThe potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments.Searching for the ideal antiepileptogenic agent in experimental models: single treatment versus combinatorial treatment strategiesDifferent microRNA profiles in chronic epilepsy versus acute seizure mouse models.Human seizures couple across spatial scales through travelling wave dynamics.Analgesic, antiallodynic, and anticonvulsant activity of novel hybrid molecules derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide in animal models of pain and epilepsy.Zebrafish as an animal model in epilepsy studies with multichannel EEG recordingsDrug-Resistant Epilepsy: Multiple Hypotheses, Few AnswersTall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsyThe pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy.Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design.Optimized methods for epilepsy therapy development using an etiologically realistic model of focal epilepsy in the rat.The roles of vitamin B12 and vitamin D in children with intractable epilepsy.International veterinary epilepsy task force consensus proposal: outcome of therapeutic interventions in canine and feline epilepsyPatterns of treatment response in newly diagnosed epilepsy.Be sure to read the fine print: the agency for healthcare research and quality comparative effectiveness report on antiepileptic drugs.Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles.Physicochemical and biological evaluation of a cinnamamide derivative R,S-(2E)-1-(3-hydroxypiperidin-1-yl)-3-phenylprop-2-en-1-one (KM-608) for nervous system disorders.Glycine transporter 1 is a target for the treatment of epilepsy.Evaluation of anticonvulsant and antinociceptive properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione.The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion.Genetic variations and associated pathophysiology in the management of epilepsy.
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P2860
Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Modern antiepileptic drug deve ...... ys out of the current dilemma.
@ast
Modern antiepileptic drug deve ...... ys out of the current dilemma.
@en
Modern antiepileptic drug deve ...... ys out of the current dilemma.
@nl
type
label
Modern antiepileptic drug deve ...... ys out of the current dilemma.
@ast
Modern antiepileptic drug deve ...... ys out of the current dilemma.
@en
Modern antiepileptic drug deve ...... ys out of the current dilemma.
@nl
prefLabel
Modern antiepileptic drug deve ...... ys out of the current dilemma.
@ast
Modern antiepileptic drug deve ...... ys out of the current dilemma.
@en
Modern antiepileptic drug deve ...... ys out of the current dilemma.
@nl
P2860
P3181
P1433
P1476
Modern antiepileptic drug deve ...... ys out of the current dilemma.
@en
P2093
P2860
P304
P3181
P356
10.1111/J.1528-1167.2011.03024.X
P577
2011-04-01T00:00:00Z