Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design

Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design

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http://www.wikidata.org/entity/Q27698019
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitorsUtilizing structures of CYP2D6 and BACE1 complexes to reduce risk of drug-drug interactions with a novel series of centrally efficacious BACE1 inhibitors.AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics.Modern advances in heterocyclic chemistry in drug discovery.Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.Constant pH Molecular Dynamics Reveals pH-Modulated Binding of Two Small-Molecule BACE1 Inhibitors.Proton-Coupled Conformational Allostery Modulates the Inhibitor Selectivity for β-Secretase.Catalytic diastereo- and enantioselective additions of versatile allyl groups to N-H ketimines.Conformational dynamics of cathepsin D and binding to a small-molecule BACE1 inhibitor.Synthesis of amino heterocycle aspartyl protease inhibitors.Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.
P2860

Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design

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http://www.wikidata.org/entity/Q27698019
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2015 nî lūn-bûn
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2015 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մարտին հրատարակված գիտական հոդված
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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name
Discovery of a series of effic ...... gh structure-based drug design
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Discovery of a series of effic ...... gh structure-based drug design
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Discovery of a series of effic ...... gh structure-based drug design
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type
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Discovery of a series of effic ...... gh structure-based drug design
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Discovery of a series of effic ...... gh structure-based drug design
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Discovery of a series of effic ...... gh structure-based drug design
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Discovery of a series of effic ...... gh structure-based drug design
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Discovery of a series of effic ...... gh structure-based drug design
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Discovery of a series of effic ...... gh structure-based drug design
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Discovery of a series of effic ...... gh structure-based drug design
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P3181
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P698