Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition
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Open access chemical probes for epigenetic targetsNMR Fragment Screening Hit Induces Plasticity of BRD7/9 BromodomainsDiscovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration AnalysisSensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibitionStructure-Based Design of an in Vivo Active Selective BRD9 InhibitorEpigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L BromodomainsChemical probes targeting epigenetic proteins: Applications beyond oncology.Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice.Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.Selective targeting of Bromodomains of the Bromodomain-PHD Fingers family impairs osteoclast differentiation.Progress in the Development of non-BET Bromodomain Chemical Probes.Targeting epigenetic regulators for cancer therapy: modulation of bromodomain proteins, methyltransferases, demethylases, and microRNAs.Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages.Selective targeting of epigenetic reader domains.Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Bromodomain inhibitors and cancer therapy: From structures to applications.Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities.Chemical modulators for epigenome reader domains as emerging epigenetic therapies for cancer and inflammation.BRD9 Inhibition, Alone or in Combination with Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors.Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.Chemical probes and inhibitors of bromodomains outside the BET family.Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex.Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple).Vitamin D Switches BAF Complexes to Protect β Cells.Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition.Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation
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P2860
Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@ast
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@en
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@en-gb
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@nl
type
label
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@ast
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@en
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@en-gb
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@nl
prefLabel
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@ast
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@en
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@en-gb
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@nl
P2093
P50
P3181
P1476
Discovery of I-BRD9, a Selecti ...... ontaining Protein 9 Inhibition
@en
P2093
Chun-wa Chung
Judit Molnar
Ka Hing Che
Laurie Gordon
Matthew Lindon
Melanie Leveridge
Natalie H Theodoulou
Nicholas C O Tomkinson
Philip G Humphreys
Rab K Prinjha
P304
P3181
P356
10.1021/ACS.JMEDCHEM.5B00256
P407
P50
P577
2016-02-25T00:00:00Z